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Biochem Step 1 HY > Glycolysis > Flashcards

Glycolysis Flashcards

1
Q

What is the first step of Glycolysis?

A

Glucose -> Glucose-6-Phosphate

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2
Q

Glucose-6-Phosphate is converted into:

A

Fructose-6-Phosphate

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3
Q

Which enzymes can convert Glucose into Glucose-6-Phosphate?

A

1) Glucokinase
2) Hexokinase

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4
Q

Glucokinase has a __(high/low) affinity for glucose.

A

Low

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5
Q

Glucokinase has a __(high/low) Km for glucose.

A

High

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6
Q

Glucokinase functions as a:

A

Glucose sensor (ONLY uses glucose at high concentrations)

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7
Q

Where is Glucokinase found?

A

1) Liver
2) Pancreatic Beta cells

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8
Q

Hexokinase has a __(high/low) affinity for glucose.

A

High

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9
Q

Hexokinase has a __(high/low) Km for glucose.

A

Low

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10
Q

Where is Hexokinase found?

A

ALL TISSUES!!!

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11
Q

If Hexokinase becomes overwhelmed, what happens?

A

Glucokinase begins to help

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12
Q

Fructose-6-Phosphate can be converted to:

A

1) Fructose-1,6-Bisphosphate
2) Fructose-2,6-Bisphosphate

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13
Q

Which RATE LIMITING ENZYME converts Fructose-6-Phosphate to Fructose-1,6-Bisphosphate?

A

Phosphofructokinase-1 (PFK-1)

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14
Q

What is the rate limiting enzyme in glycolysis?

A

Phosphofructokinase-1 (PFK-1)!!!!

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15
Q

What activates Phosphofructokinase-1 (PFK-1)?

A

1) AMP
2) Fructose-2,6-Bisphosphate

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16
Q

What inhibits Phosphofructokinase-1 (PFK-1)?

A

1) ATP
2) Citrate

17
Q

What converts Fructose-6-Phosphate to Fructose-2,6-Bisphosphate?

A

Phosphofructokinase-2 (PFK-2)

18
Q

What activates Phosphofructokinase-2 (PFK-2)?

A

Insulin

19
Q

What inhibits Phosphofructokinase-2 (PFK-2)?

A

Glucagon

20
Q

What is the last step in glycolysis?

A

Phosphoenolpyruvate -> Pyruvate

21
Q

Which enzyme converts Phosphoenolpyruvate to Pyruvate?

A

Pyruvate Kinase

22
Q

What inhibits Pyruvate Kinase?

A

1) ATP
2) Citrate

Biochem Step 1 HY (15 decks)

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