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Biochem Step 1 HY > Gluconeogensis > Flashcards

Gluconeogensis Flashcards

1
Q

Gluconeogenesis occurs mainly in which organs?

A

1) Liver
2) Kidney

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2
Q

In which state does gluconeogenesis usually occur?

A

The fasting state

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3
Q

What cannot undergo gluconeogenesis due to absence of Glucose-6-Phosphatase?

A

Skeletal muscle

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4
Q

Skeletal muscle cannot undergo gluconeogenesis due to absence of:

A

Glucose-6-Phosphatase

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5
Q

What is the first step of gluconeogenesis?

A

Pyruvate -> Oxaloacetate

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6
Q

What does gluconeogenesis start with?

A

Pyruvate

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7
Q

What converts Pyruvate to Oxaloacetate?

A

Pyruvate Carboxylase

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8
Q

How does Pyruvate become Phosphoenolpyruvate?

A

By becoming Oxaloacetate first

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9
Q

What converts Oxaloacetate to Phosphoenolpyruvate?

A

Phosphoenolpyruvate Carboxykinase

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10
Q

What converts Fructose-1,6-Bisphosphate to Fructose-6-Phosphate?

A

Fructose-1,6-Bisphosphatase

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11
Q

What converts Glucose-6-Phosphate to Glucose?

A

Glucose-6-Phosphatase

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12
Q

What is the rate limiting enzyme of gluconeogenesis?!?!!!!!!!!!

A

Fructose-1,6-Bisphosphatase!!!!

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13
Q

What activates Fructose-1,6-Bisphosphatase?

A

Citrate

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14
Q

What inhibits Fructose-1,6-Bisphosphatase?

A

1) AMP
2) Fructose-2,6-Bisphosphate

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15
Q

What does Phosphoenolpyruvate Carboxykinase require in order to function?

A

GTP!!!

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16
Q

What activates Pyruvate Carboxylase?

A

Acetyl-CoA

17
Q

What does Pyruvate Carboxylase require in order to function?

A

Biotin!!!

18
Q

Which overall hormone is responsible for Gluconeogenesis?

A

Glucagon

Biochem Step 1 HY (15 decks)

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