HMP Shunt Flashcards
What are the important products of the HMP shunt?
NADPH
Ribose-5-phosphate
Where is the HMP shunt generally active?
Tissues maintaining reduced glutathione
Tissues synthesizing FAs, cholesterol, and steroids
Tissues involved in detoxification using cytochrome P450
How many glucose enter into the HMP shunt and how many are produced at the end?
6 enter
5 produced
What is the first reaction of the HMP shunt starting with G6P?
G6P to 6P-gluconolactone by G6P dehydrogenase using NADP to NADPH
What is the second reaction of HMP shunt?
6P-gluconolactone to 6P-gluconate by the removal of H2O
What is the third reaction of the HMP shunt?
6P-gluconate to ribulose 5P by 6Pgluconate dehydrogenase using NADP to NADPH and releasing CO2
What is the fourth reaction of the HMP shunt?
6 Ribulose 5P to 2 ribose 5P by isomerase and 4 Xylulose 5P by epimerase
What is the fifth reaction of the HMP shunt?
2 Xylulose 5P to 2 Glyceraldehyde 3P
2 Ribose 5P to 2 Sedoheptulose 5P
What is the coenzyme required by transketolase?
TPP
What are the reactions done by transaldolase?
Glyceraldehyde 3P to erythrose 3P
Sedoheptulose 5P to Fructose 6P
What is the reaction catalyzed by transketolase using Erythrose 4P?
2 Erythrose 4P and the 2 remaining Xylulose 5P to 2 F6P and glyceraldehyde 3P
How is glucose remade?
F6P into G6P into glucose
What is the regulatory enzyme of the HMP shunt?
G6PD
What induces the transcription of G6PD?
Insulin
What is the importance of maintaining reduced glutathione?
Important antioxidant, particularly in RBCs
