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PHM 604 > HIV medications > Flashcards

HIV medications Flashcards

1
Q

INSTIs

A

-Bictegravir
-Daltegravir
-Raltegravir

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2
Q

Which INSTI are preferred in pregnancy?

A

Daltegravir
Raltegravir

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3
Q

Which NRTI requires testing?

A

Abacavir (ABC) for HLA-B*5701

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4
Q

What DDIs occur with Inetgarse Inhibitors

A

-PPIs (Omeprazole & Pantopraxole)
-Cation Antacids (Al, Mg, Ca)

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5
Q

Side effects of Integrase Inhibitors?

A

GI disturbances
CNS disturbances
Weight gain
Rash (rare)
False creatinine elevation

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6
Q

Which integrase inhibitor(s) have low resistance barrier?

A

Raltegravir

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7
Q

Which integrase inhibitor(s) are in single-tab regimens?

A
  • Bictegravir
  • Daltegravir
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8
Q

NRTIs in Pregnancy

A

-Emtricitabine (FTC)
-Tenofovir alafenamide (TDF)
-Lamivudine (3TC)

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9
Q

Pregnancy to Potential Pregnancy ART Regimen?

A

NRTI Backbone + INSTI
OR
NRTI Backbone + Boosted PI

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10
Q

True or False. There are increased clinical outcomes with rapid ART initiation.

A

True

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11
Q

Single Tablet regimen
INSTI + single NRTI

A

DTG/3TC

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12
Q

DTG/3TC caveat?

A

Do not use if HIV1-RNA (viral load) is >500,000

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13
Q

single tablet regimen
INSTI + dual NRTI

A

DTG/3TC/ABC

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14
Q

DTG/3TC/ABC caveat?

A

Use only if HLA-B*5701 test is negative

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15
Q

single tablet regimen
NNRTI + single NRTI

A

RPV/FTC/(TAF or TDF)

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16
Q

RPV/FTC/(TAF or TDF) caveat

A

Only use if HIV1-RNA (viral load) is <100,000 and CD4 >200 cells

17
Q

Support for TDF?

A

generic NRTI combo with 3TC and FTC

18
Q

Support for TAF?

A

less impact on markers of renal tubular dysfunction

19
Q

Support for ABC

A

Long history and is not renally cleared but requires HLA Testing (grade 1 - 5 threatening rxn)

20
Q

Entry Inhibitors

A

-Enfuviritide
-Maraviroc
-Ibalizumab

21
Q

Use of Entry Inhibitors?

A

Mainly used in heavily treatment-experienced patients

22
Q

When to consider Boosted PIs

A

Starting ART before availability of resistance data

23
Q

Challenges with Boosted PI use

A

-DDIs (CYP3A)
-GI Intolerances
-Hyperlipidemia
-Cv risk with some

24
Q

Striblid or Genvoya

A

-Elvitegravir
-Cobicistat
-Emtricitabine
-Tenofovir

25
Q

Striblid or Genvoya. Low fat meal or high fat meal?

A

High fat meal

26
Q

Striblid or Genvoya CrCl

A

> 70 at baseline and not <50

***Slight increase in SCr during therapy

27
Q

True or False. Oral ART and Long-Acting ART have similar efficacy

A

True

***Long-Acting - once a month

28
Q

Striblid or Genvoya Extensive DDIs

A

-Inhibits 3A, 2D6, pGp
-Induces 2C9

29
Q

NNRTIs

A

EFV
RPV
DOR

30
Q

Primary goals of HIV Treatment

A

Maximal and durable viral suppression
Restoration and preservation of immune function (CD4 count)
Improved QOL
Reduced HIV-related opportunistic infections
Reduced morbidity and mortality

31
Q

Recommended regimen for first-line ART

A

BTC/FTC/TAF
DTG/ABC/3TC

***INSTI + 2NRTIs

PHM 604 (11 decks)

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