HIV - Brand/Generic Flashcards
Protease Inhibitors
- MOA
- Take w/:
- Excrete:
- Sulfa allergy
- Protease enzyme breaks down the protein into function units to be used for final assembly of new virus. Protease inhibitors inhibit this enzyme
- All take w/ food except Indinavir and Fosamprenavir suspension
- All excrete the LIVER
- Sulfa allergy: fosamprenavir, darunavir, tiprinavir
AgenerASE
AMprenavir
=> Cha Am dan dan bi erASE ddi
CRIXivan
- SE
INDInavir
- Kidney stone (Nephrolithiasis) => take w/ plenty of wate
Kaletra
Storage
- Suspensions
- Cap
Lopinavir-Ritonavir
- Susp Sol’n => take w/ FOOD; REFRIGERATION b/c it contains EtOH
- Film coated capsule: do not refrigerate
Viracept
Nelfinavir
- Bad diarrhea
NORvir
- Storage
- SEs
RITonavir
Storage:
- Cap: refrigerate
- Tab/Sol: RT
SE
- Has bad GI, paresthesias
Invirase
SaQUINavir
Aptivus
- SEs
- BBW
TIPranavir
- Has EtOH
SE
- Fatal hepatotoxicity
- Sulfa allergy
BBW: intracranial hemorrhage
Lexiva
FoSAMprenavir
- Sulfa allergy
- Suspension take on empty stomach
ReyaTAZ
- SEs
ATAZanavir
- Doesn’t increase lipid
- Take QD
SEs
- Cardiac abnormalities
- Most DDI
Prezista
- SEs
- Direction to take
DaRUNavir
- Sulfa allergy
- Take BID with FOODs and ritonavir
Nucleoside Reverse Transcriptase Inhibitors (NRTI’s)
- SE
- Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)
- Lactic acidosis
Zerit
STAvudine
- SEs: GI intolerance Pancreatitis Peripheral neuropathy Lactic acidosis Lipodystrophy
EPivir
LAMivudine
Retrovir
ZiDOvudine
Videx
- Direction to take
- SEs
DiDANosine
- Take on empty stomach
- SEs: Pancreatitis, peripheral neuropathy, retinal pigmentation, and lactic acidosis
Ziagen
Abacavir
- SEs: Hypersensitivity rx HLA B*5701. D/c and do not re-challenge
Viread
- SEs
Tenofovir
- SEs: lactic acidosis, hepatotoxicity.
Acute renal failure/Fanconi syndrome
Osteoporosis
EMTRIva
EMTRIcitabine
Integrase inhibitors
- MOA
- Inhibit HIV DNA integrate into host cell DNA
Insentress
- MOA
Raltegravir
- MOA: Inhibit HIV DNA integrate into host cell DNA
Tivicay
- MOA
- Age
- SEs
Dolutegravir
- MOA: Inhibit HIV DNA integrate into host cell DNA
- Age: for pt > 12 y.o
- SEs: HA, insomnia
Entry Inhibitors
- MOA
- Inhibit HIV binding and fusion therefore HIV can’t get inside celly
Fuzeon
- MOA
- SEs
Enfuvirtide
- MOA: Target the gp120 or gp41 proteins on HIV’s surface
- SE: may cause infection
Selzentry
- MOA
- Rec dose
- Take with inhibitors
- No inhibitors/inducers
- Take with inducers
- SEs
MAraviroc
- Is CCR5 (Chemokine receptor type 5) blocker & antagonist
- CCR5: is a protein which HIV uses to enter its target cells
- Rec initial dose is 150mg BID if also on inhibitors
- Rec dose is 300mg BID
- Rec initial dose 600mg BID if also on inducers
- SE: hepatotoxicity, heart problem, orthostatic hypoTN
Non- Nucleoside Reverse Transcriptase Inhibitors (NNRTI’s)
- MOA
- Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)
Viramune
NeVIRApine - ne VYE ra peen
Intelence
- SEs
ETRAvirine - et tra VIR reen
- SEs: severe skin RASH
Rescriptor
- SEs
Delavirdine
- SE
Rash, hepatotoxicity (least)
SUstiva
- SEs
- Preg Cat
- Direction to take:
EFAvirenz
- SEs: CNS sx: vivid dream, hallucination, false cannabinoid test
- Preg Cat D
- Take on empty stomach
Eduran
- SEs
Rilpivirine - Ril pi VIR reen
- SEs: depression, insomnia
Glycoproteins gp41
- Function
- Helps to initiate the process of membrane fusion b/w virus and cell
Combivir
=> Come LZ
Zidovudine + Lamivudine
EPizicom
=> EP co Lam
Abacavir + Lamivudine
TriZivir
LAZ = Trinity last
Zidovudine + Lamivudine + Abavavir
Truvada
- Combo
- Indication
=> TE
- Tenofovir + Emtricitabine
Indication
- FDA approved for PREVENTION of HIV infection in adults 1 tab PO QD
Atripla
- Gold standard
- Never give to
- Take w/ ?
Efavirenz + Emtricitabine + Tenofovir
- Never give to preg woman
- Take QD on Empty stomach
CompleRa
- Take with
- Emtricitabine + Tenofovir + Rilpivirine
- Take with FOOD 1 tab QD
Stribild: (TEEC)
- Take w/
- CrCl
- Elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate
- Take with FOOD 1 tab QD
- CrCl
Fxn of Cobicistat
- Enhancer to prolong the effect of Elvitegravir + emtricitabine + tenofovir
Vitravene
- How to give
- Indication
Fomivirsen
- A shot directly into the disease eye x 2 separate by 2W
- Approved for CMV who have failed other therapy
Rebetol, Copegus
- Indication
- SEs
- Preg Cat
Ribavirin
- Indication: Hepatitis C use in combo with interferon
- SEs/CI: Sig heart disease
- Preg Cat X
Pegylated Interferon
- Brand
- SEs
Pegasys; PEG-Intron
- Depression & suicidal behavior
Egrifta
- MOA
- Indication
- Dosage
- CI
Tesamorelin Injection
- MOA: growth hormone releasing factor analog
Indication
- Reduces excess abdominal fat in HIV-infected patients with lipodystrophy
Dosage:
- 2mg SC QD
CI
- Pregnant
- Active malignancies
Fulyzaq
- Indication
Crofelemer
- Indication: Anti-diarrha for symptomatic relief of non-infectious diarrhea in pts with AIDs/HIV on anti-retrovial therapy
Dapsone
- Indication
Sulfadiazine
- CMV ppx
Daraprim
- Indication
- MOA
Pyrimethamine
- Indication: antimalaria
- Use in combination with leucovorin + sulfadiazine for toxoplasmosis treatment
- MOA: inhibits parasitic dihydrofolate reductase
Foscarvir
Foscarnet
- CMV
- SEs: Nephrotoxic, seizure
Cytovene
- Direction to take it
Ganciclovir
- Take with FOOD
Vistide
Cidofovir
- CMV
- SE: severe nephrotoxicity = must taken with probenecid to help prevent kidney damage
Valcyte
Ganciclovir
- CMV
Vitrasert
Ganciclovir implants
Vitravence
Fomiversen
- Shot directly into the eye x 2 separate by 2wks
Triumeq
Abacavir + Lamiviudine + Dolutegravir
