HIV

Question 1

Gag

Answer 1

Cleaved by a viral protease into…
• P24 – Capsid Protein
• P17 – Matrix Protein
• P7 – Nucleocapsid (binds to the viral RNA genome)

Question 2

P24

Answer 2

Capsid Protein

Question 3

P17

Answer 3

Matrix Protein

Question 4

P7

Answer 4

Nucleocapsid (binds to the viral RNA genome)

Question 5

Pol

Answer 5

Gene that contains the enzymes including viral protease (*reverse transcriptase) and viral integrase proteins. Also cleaved by viral protease

Question 6

Env

Answer 6

Starts as gp160 but gets cleaved into…
• GP41 – Envelope glycoproteins
• GP120 – Enveloped glycoproteins

Question 7

GP41

Answer 7

Envelope glycoproteins

Question 8

GP120

Answer 8

Enveloped glycoproteins

• Viral attachment protein

Question 9

LTR

Answer 9

“Long Terminal Repeat”
FX
- Initiation Site for Transcription that contains site for binding transcriptional regulatory proteins; long terminal repeat

Question 10

tat

Answer 10

“Trans-Activator of Transcription
FX
- Transcriptional activator by binding TAR elements and promoting transcriptional elongation

Question 11

rev

Answer 11

“Regulator of Viral Gene Expression”

- Promotes transport of unspliced mRNAs from nucleus to cytoplasm

Question 12

Nef

Answer 12

“negative factor”
FX
- Downregulation of cellular CD4 and MHC 1 proteins