HIV Flashcards
what family?
retroviradae
type of nucleiec acid?
ss RNA
where is replication?
nucleus
where is assembly?
cytoplasm
what receptor does it bind to on entry?
CD4
is latency possible? if so where?
yes - memory T cells (central and transitional)
2 proteins he didnt shut up about? what are they involved in
TAT and REV. TAT involved in transcription. REV - Regulates Expression of Virion proteins
what does HIV cause in the gut during the ‘fast slow phase’ (2)?
loss of peyers patches. breakdown of tight junctions
3 stages of HIV infection
primary, asymptomatic, symtpmatic (and aids)
what is acute HIV characterized by (cellularly)?
a rapid massive loss of body’s CD4 T cells
what is a HIV viral load?
amount of RNA in plasma
name 3 ways HIV avoids immune response
high mutation rate, latency, altered antigen presentation
4 targets for anti HIV drugs
fusion/entry inhibitors, reverse transcriptase inhibitors, integrase inhibitors, protease inhibitors
dif b/w NRTI and NNRTI
(Non) Nucleoside Reverse Transcriptase Inhibitors. The non dont bind to the nucleotide binding site of reverse Transcriptase and arent DNA analogues. NRTIs are DNA analgoues
rationale for combination treatment?
reduce drug resistance. drugs are thus more potent
