Breast Path

Question 1

where do most lesions arise from?

Answer 1

epithelium of the terminal duct lobular unit

Question 2

what is fibrocystic change? give 4 features

Answer 2

benign. multifocal and bilateral. fibrosis with cyst formation

Question 3

what is a fibroadenoma? give 4 features including presentation

Answer 3

benign - usually in younger women. solitary well circumscribed mass. presents as lump

Question 4

name 4 key genes associated with breast cancer

Answer 4

HER2, p53, BRCA1 and BRCA2

Question 5

r/ship b/w oestrogen and breast cancer?

Answer 5

the more exposure the greater the link

Question 6

define a carcinoma in situ. name the 2 types

Answer 6

Malignant population of cells confined to ducts and/or acini, w/o invasion through basement membrane.
Ductal Carcinoma in Situ.
Lobular Carcinoma in Situ

Question 7

what are the 2 invasive carcinomas? which is more common

Answer 7

same as non-invasive. Ductal and lobular. Ductal much more common

Question 8

name 6 risk factors for breast cancer?

Answer 8

Age, genetic factors (sporadic and familial), oestrogen, diet (alcohol and obesity), past breast disease