Genes that predispose to Cancer

Question 1

name 3 mechanisms for gene mutation

Answer 1

chromosomal translocation, point mutation and viral/bacterial

Question 2

6 established hallmarks of cancer

Answer 2

evading apoptosis, angiogenisis, evading growth inhibition, autonomous growth signalling, Activating Invasion +
Metastasis, immortality (unlimited replicative potential)

Question 3

4 emerging hallmarks

Answer 3

avoiding immune destruction, tumour promoting inflammation, genome instability, deregulating cellular energetics

Question 4

role of p 53?

Answer 4

guardian of genome. invokes apoptosis or DNA repair, also inhibits growth signalling

Question 5

Philadelphia chromosome is involved in which leukaemia? 2 chromosomes and genes involved

Answer 5

CML. 22;9 Bcr-Abl

Question 6

Gleevec (imatinib) is a treatment for which leukaemia? what is its MOA

Answer 6

CML. A specific Bcr-Abl tyrosine-kinase inhibitor

Question 7

does gleevec cure CML?` why/not?

Answer 7

progenitor cell is protected from Gleevec. Therefore Gleevec doesnt cure. Must be taken continuously to remove downstream effect

Question 8

BH-3 only mimetic ABT-199 is a drug in clinical trial for which disease?

Answer 8

CLL

Question 9

Main gene involved in CLL? what happens

Answer 9

Bcl-2 - over-expression prevents apoptosis

Question 10

miRNA(15,16), ZAP -70 and p53 involved with which cancer?

Answer 10

CLL