Blood Flashcards
how much blood is made? how often
red cell 3-5 x 10^12 p/L. 120 days
White 2-6 x 10^9 p/L. 3-5 days
Platelets 150-400 X 10^9 p/L. 10 days
sites of Haemopoiesis throughout life
Yolk Sac - first few weeks.
Liver and spleen - 6weeks-7 months.
Bone marrow - 7 months- throughout life
where in body is bone marrow? child adult?
adult - axial trunk. Child - long bones + axial trunk
where take bone marrow aspirate?
PSIS
what makes up half of bone marrow
fat
what is a pluripotent stem cell? 2 important facts?
Cell that differentiates to all lineages of blood cells. Capable of self renewal, can’t be identified
what does CFU stand for in regard to haemopoiesis
colony forming unit
main 2 lines the pluripotent differentiates into
lymphoid and myeloid
bone marrow is in continuous circulation with blood. Why dont the cell get swept away?
adhesion molecules to bone marrow stroma
describe what Haemopoetic growth factors do?
signal via 2ndary messengers when or to what a cell should differentiate. a certain factor can act on multiple lineages or do different things depending on stage of cell maturity
name 3 haemantics
iron, B12, folate
non anaemic sign of iron defficiency
pica
components of a RBC (3)
membrane, haemoglobin, enzymes
vitamin b12 obtained from where? important for what
meat, fish dairy. important for all cell production
some with blood group A+ is what genotype? produces which antigens and antibodies? can receive from who?
AA or AO and DD or Dd. They have A antigens and produce B antibodies. Can receive either A or O, postive or negative.
