HIV

Question 1

Which class of medications is historically considered the backbone of ARV therapy regimens?

Answer 1

Nucleoside/Nucleotide Reverse Transcriptase Inhibitors

Question 2

Class adverse effects of NRTIs

Answer 2

. Pancreatitis
. Lactic acidosis

Question 3

Abacavir (Ziagen) is (renally/hepatically) eliminated

Answer 3

Hepatically

Question 4

Lower (TAF/TDF) serum concentration improves bone and kidney safety profile

Answer 4

TAF (tenofovir alafenamide)

Question 5

TAF administration pearl

Answer 5

Best absorbed with a high fat meal

Question 6

NNRTIs are CYP (inhibitors/inducers)

Answer 6

Inducers

Question 7

Protease inhibitors are CYP3A4 (inhibitors/inducers)

Answer 7

Inhibitors

Question 8

Class adverse effects of NNRTIs

Answer 8

. Rash
. Hepatotoxicity
. Dizziness

Question 9

Integrase inhibitor examples

Answer 9

• Raltegravir (Isentress®, Isentress HD®)
• Elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide (Stribild®)
• Dolutegravir (Tivicay®)
• Bictegravir, emtricitabine, tenofovir alafenamide (Biktarvy®)
• Cabotegravir (Vocabria®, Apretude®)

Question 10

Which gene mutation should be tested for prior to initiating an agent with abacavir?

Answer 10

HLAB*5701

Question 11

Class interaction with integrase inhibitors

Answer 11

Coadministration with poly-cations can result in chelation

Question 12

CD4 count < ____ cells/mm^3 is indicative of AIDS

Answer 12

200 cells/mm^3

Question 13

Viral load goal for patients with HIV

Answer 13

Undetectable