Arthritis Med Chem Flashcards
1
Q
True or false: Osteoarthritis is an inflammatory disease
A
False. Disease of cartilage
2
Q
Rheumatoid arthritis pathophysiology
A
Chronic systemic autoimmune inflammatory disease that leads to cartilage, bone and joint damage
3
Q
Psoriatic arthritis pathophysiology
A
Chronic, inflammatory disease of the joints and entheses (where tendons and ligaments connect to bone)
4
Q
Most NSAIDs are racemic mixtures except
A
Naproxen is the only single enantiomer
5
Q
Which NSAIDs are prodrugs?
A
.Sulindac
.Nabumetone
6
Q
Celecoxib can increase concentrations of various agents, including antidepressants, because of its inhibition of which CYP enzyme?
A
CYP2D6
7
Q
Celecoxib is contraindicated in what allergy?
A
Sulfa allergy. Celecoxib is a sulfonamide
8
Q
What is the cornerstone of modern RA treatment?
A
DMARDs
9
Q
A
