Histopathology CNS Cases (Week 5--Vinters)

Question 1

Two causes of stroke

Answer 1

1) Atherosclerosis –> infarcts by direct occlusion of an artery feeding specific area of the brain
2) Thromboemboli (artery-to-artery emboli) –> focal brain necrosis –> permanent focal neurological deficit

Question 2

Examples of focal neurologic deficits

Answer 2

Aphasia

Hemiparesis

Hemiplegia

Question 3

How do you detect Lewy bodies (characteristic of Parkinson’s disease)

Answer 3

Use antibody to alpha synuclein in nerve cells

Question 4

Two lesions that accumulate in CNS of patients with Alzheimer’s

Answer 4

Senile “neurotic” plaques

Neurofibrillary tangles

Note: both of these contain A-beta protein