Histopathology Flashcards
Besides interface dermatitis, what other histopath feature typically occurs in ECLE?
Sebaceous adenitis
How does histopath of dermatomyositis differ from that of VCLE?
Dermatomyositis: cell POOR interface dermatitis + ischemic follicular atrophy
VCLE: Lymphocyte RICH interface dermatitis without ischemia
Where does the vesiculation occur in VCLE on histopath?
Intrabasal
What is are characteristic histopath features of cutaneous lupus?
Lymphocyte-rich interface dermatitis with basal keratinocyte damage
What is the histopathologic hallmark of canine sarcoidosis?
Naked granulomas (i.e. macs without lymphocytes at the periphery of the granuloma)
How would you differentiate histiocytoma from reactive histiocytosis on histopath?
Histiocytoma is top-heavy and the neoplastic cells have epitheliotropism
Is a lymphoplasmacytic lichenoid dermatitis specific for discoid lupus erythematosus?
No – this inflammatory pattern can be reflective of ANY mucosal inflammation (so need to look for other features like basal cell damage)
Describe the key histopath features of EM
Cytotoxic interface dermatitis (multi-level/transepidermal apoptosis) with satellitosis
What is a primary difference between EM and TEN on histopath?
Less inflammation and more necrosis in TEN
How is TEN distinguished from a burn on histopath?
TEN lacks dermal necrosis (but epidermal necrosis is a feature of both
How is EM distinguished from lupus erythematosus on histopath?
Lupus: apoptosis limited to basal layer
How can you use sebaceous glands to differentiate a biopsy of a dog from that of a cat?
Sebaceous glands: Dogs have vacuolated seb glands, cats have neat tidy sebaceous glands
How can you use hair follicles to differentiate the species on biopsy?
You find skeletal muscle on biopsy. Where is it likely from?
Face (chin) or perianal
You find arrector pili muscle on biopsy. Where is it likely from?
Dorsum
A biopsy has a thickened epidermis with a stratum lucidum present. Where was it taken from?
Paw pad
You find a sinus hair on a biopsy. Where is it from?
Face (OR carpus in cats)
Describe the histopathologic findings for Golden Retriever ichthyosis
Lamellar orthokeratotic hyperkeratosis, no inflam, no epidermal hyperplasia
Describe the histopath features of acral lick granuloma
Irregular hyperplasia of the epidermis and follicular infundibula
Compact hyperkeratosis and multifocal parakeratosis
Vertical streaking
Where are inclusion bodies found for poxvirus?
Within the cytoplasm
What phase is this hair in?
Telogen (retraction of papilla, trichilemmal keratinization)
What glands are highlighted in this image?
Epitrichial (dog paw pad)
