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MK ACVD Exam > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What is the MOA of lidocaine/pramoxine?

A

Sodium channel antagonist –> interferes with impulse production and action potential in nerves

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2
Q

What is the MOA of capsaicin?

A

TRPV1 agonist on C nerve fibers –> depolarization and neural desensitization

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3
Q

What is the MOA of topical menthol?

A

TRPM8 antagonist –> cooling sensation (no major benefits in dogs to date)

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4
Q

What is the MOA of antihistamines?

A

H1 receptor antagonists –> competitively block formation of histamine-receptor complex

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5
Q

What is the MOA of maropitant for itch?

A

Neurokinin-1 receptor inhibitor

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6
Q

What is the MOA of lokivetmab?

A

Anti-canine IL-31 mAB –> binds to circulating IL-31 and prevents it binding to its receptor

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7
Q

What is the MOA of ranevetmab?

A

Anti-canina nerve growth factor mAB (fails to prevent atopic itch)

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8
Q

What is the MOA of gabapentin and pregabalin?

A

GABA analog (inhibitory neurotransmitter) –> inhibits voltage-gated Ca channels in spinal cord –> reduces central neural hypersensitization

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9
Q

What is the MOA of topiramate?

A

NMDA receptor antagonist –> increases GABA activity and inhibits glutamate activity –> less neuronal excitability

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10
Q

What is the antipruritic MOA of butorphanol?

A

Mixed kappa-opioid agonist and mu-opioid antagonist

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11
Q

Would naloxone be potentially antipruritic?

A

Yes because it is a mu-opioid antagonist

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12
Q

What is the antipruritic MOA of amantadine?

A

NMDA receptor antagonist –> less neuronal excitability

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13
Q

What is the MOA of amitriptyline?

A

Tricyclic SSRI –> inhibits reuptake of serotonin –> increased neural impulses

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14
Q

What is the MOA of clomipramine?

A

Tricyclic SSRI –> inhibits reuptake of serotonin
(potent SSRI but not very specific)

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15
Q

What is the MOA of fluoxetine?

A

Bicyclic SSRI–> inhibits reuptake of serotonin
(very selective)

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16
Q

What is the MOA of doxepin?

A

SNRI –> inhibits reuptake of serotonin and norepi –> increased neurotransmission
Also has potent anti-H1 receptor properties

17
Q

What is the MOA of mirtazapine?

A

SNRI –> antagonizes serotonergic and noradrenergic receptors
(useful for nocturnal pruritus)

18
Q
A

MK ACVD Exam (7 decks)

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