Histology review Flashcards
exam 2
ectoderm
external
“internal”
endoderm
internal
mesoderm- mesothelial cells
epithelia
avascular, polarized and express keratin
all nuclei are in a row
simple
wandering
lymphocytes
epidermis
SSKE
esophagus
SSNKE
SSNKE
all the way to the free surface, living, see the nuclei
SSKE has a
dark pigmented line
pseudostratified
all cell contact basal lamina, not all reach the surface
transitional
large surface cells and binucleate
urothelium
translitional
unicellular you will see
goblet cell
pancreas duct
multicellular compound
dermal sebaceous gland
multicellular simple
exocrine pancreas
merocrine
exocrine pancreas shows what type of cells?
simple columnar
decapitation secretion
apocrine
mammary gland: milk
apocrine e
dermis-sebaceuos gland
holocrine
serous secretion (4)
- watery secretion
- abundant rer
- round nucleus
- cell well stained
mucous (4)
- thick secretion
- clear cytoplasm
- flat nucleus
- cells poorly stained
zonula occludens and zonula adherens will always be present in
the plane of section
makes the dots beneath the terminal bar
zonula occludens and zonula adherens
tight junction
zonula occludens
transmembrane proteins (2)
- occludin
- claudin
transmembrane proteins are attached to
actin
calcium dependent intercellular junction
Zonula adherens
E-cadherin
Zonula adherens
zonula adherens is
continuous with actin cytoskeleton
zonula adherens job
transduce signals from adjacent cells
gap junction
communicating junction
communicating junctions job
facilitates transcellular movement of:
- metabolites
- 2nd messengers
- ion
basal lamina you only see in
EM
basal lamina is
discontinuous
reticular lamin
collagen III
basal lamina + reticular lamina
basement membrane
indigenous cells (5)
(1) fibroblast
(2) adipocytes
(3) mesenchymal cells
(4) osteogenic cell and derivatives
(5) chondrogenic cell and derivatives
Immigrant cells (7)
plasma cells mast cells macrophages basophil lymphocytes eosinophil neutrophils
indigenous cells key point
will always be in the CT
Most common cell in most CT
fibroblasts
have the capacity to differentiate into myofibroblasts but only in ______
fibroblasts in wound healing
collagen II is made by
chondrocytes
chicken-wire
white adipose tissue
brown adipose tissue has a lot of
capillaries
plasma cells are
differentiated B-lymphocytes
“cock-face”
Plasma face
round granules, one nuclei and the nuclei is smaller to cytoplasm
mast cells
basophils are found in the
blood
macrophages differentiates from
blood monocytes
they have phagocytic vacuoles, esosinophilic cytoplasm
macrophages
recirculate from blood to CT and back to blood
lymphocytes
lymphocytes are subsets of
B and T cells
small, dark nuclei, and little cytoplasm
lymphocytes
triple helix
collagen fibrils
collagen fibrils will have
dark and light bands
collagen fibers
dense regular/irregular
Type I collagen is made by
fibroblasts and osteoblasts
reticular fibers will stain
silver
ground substance
- proteoglycans, glycosaminoglycans and glycoproteins
- water
lamellar elastic fibers
lasagna like
fibrillar elastic fibers
sporadic fibers, branched like a v
fibrillin-1 sequestering TGF-beta
marfan syndrome
loose (areolar) CT
a lot of ground substance
dense regular CT
smooth, with nuclei all going in one direction
Dense irregular CT
fibers and nuclei going in all directions
Neutrophils location
about half will be in blood and the other CT
multi-lobe, and you can see the barr bosy
neutrophils
lymphocytes location
abundant in both blood and CT
horse-shoe nuclei
monocytes
fine granules and the precursor cell to macrophages, osteoclasts and dendritic cells
monocytes
monocytes location
only in blood
bi-lobed nucleus, bright red in cytoplasm, rod-shaped granules with a line core
eosinophils
basophils will be seen in the
blood moslty
bilobed nucleus, multiple round granules
basophils
formed in bone marrow as fragments
platelets
cartilage will contains
- collagen II
- sulfated proteoglycans
cartilage is both
avascular and aneural
hyaline cartilage contains
- chondrocytes “back to back D”
- cells retracted from lacunae “floating nuclei”
- interstitial and appositional growth
- interterritorial matrix
- perichondrium
elastic fibers will be like hyaline cartilage but
it has elastic fibers “V”
fibrocartilage has no
perichondrium
fibrocartilage has both
fibroblasts and chondrocytes thus making both collagen I and collagen II
fibrocartilage grows
interstitially
lamellar (2)
compact
spongy
woven
immature bone and disorderly arrangement of collagen
cancellous, trabecular
spongy
Compact will contain
haversian systems
interstetially lamellae is mostly formed by
remolded haversian system, incomplete osteon
osteon
1 haversian system
lacunae is where
osteocytes live
volkman canal attach two haversian systems
perpendicular
spongy contains bone lamellae but no
haversian systems
woven bone will contain a
mesenchyme
mixed specule
endochondral ossification
osteogenic cells
mesenchyme derivative
osteoclasts
MPS- derivative
endochondral ossification
-cartilage template first
epiphyseal growth zones (4)
- resting
- proliferation
- hypertrophy
- calcification
mixed spicule fate
either compact or spongy
spongy bone remodeling
osteoclast is counter-acted by osteoblast leading to no change in mass of the spicule
suppress activity of
osteoclast
decreased number/function of osteoclasts
osteopetrosis
no cartilage template
intramembranous ossification
mixed spicule in
intramembranous ossification
intramembranous ossification
- initial bone is woven
- “de novo”- condensing mesenchyme
intramembranous ossification can be both
spongy or compact
maintenance of calcium levels
blast vs clast
striated voluntary
skeletal
continuous external lamina- completely insulated
skeletal
true synctium
skeletal
functional synctium
cardiac
the white space around the myofibrils represents
SR
triad
skeletal
all CT investments unite at
tendons
contractile proteins are linked to the ECm by
dystrophin complex
what is the moving compartment of sarcomere?
actin
nucleus a the periphery in muscle
skeletal
endocrine cell
cardiac muscle cell
contractile and conduction
purkinje fibers
muscle has no CT
smooth
discontinuous external lamina and many gap junctions
smooth
dense bodies contains _____ and it is found in
contains actin and found in smooth
z-disk equivalent in smooth
dense bodies
what can you find in caveole?
sarcoplasmic reticulum
multipolar
motor neurons
surrounds nerve fibers
perinerium
individual axon surrounded by
endonerium
unmyelinated fibers
autonomic
myelinated fibers
somatic sensory/motor
incisures within myelin run oblique angles
schmidt-lanterman
exposes the axon due to no myelin
node of ranvier
dorsal roo ganglion
sensory ganglion
neurons with central neurons and complete ring of satellites… NO DENDRITES!!!!
Sensory ganglion
pseudopolar
sensory
neurons with eccentric nucleus and incomplete ring of sattelites, dendrites
autonomic
gut
enteric
exist between two smooth muscle running perpendicular
enteric plexus