Histology of the CNS Flashcards

1
Q

most common excitatory NT

A

glutamate

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2
Q

meissner’s corpuscles (light touch) cell bodies are located in..

A

the DRG

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3
Q

glial cells vs neurons on cell division

A

neurons rarely divide; glial cells divide

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4
Q

spinal cord H is made up of

A

grey matter (unmyelinated)

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5
Q

axons are made up of ____ that form _____

A

white matter; white matter tracts (like the corticospinal tract)

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6
Q

upper motor neurons are contained in the

A

brain

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7
Q

lower motor neurons are contained in the

A

spinal cord

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8
Q

the cerebral cortex cell bodies are made of which type of matter?

A

grey matter (cortex is on outside/ made of neuron cell bodies)

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9
Q

the PNS consists of

A

axons (to skeletal muscle is referring to motor neurons)

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10
Q

stain used to stain myelin of the axons

A

cresyl violet stain

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11
Q

a cluster of neurons outside the CNS is termed

A

ganglion

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12
Q

a cluster of neurons inside the CNS is termed

A

nucleus

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13
Q

smooth muscle/gland motor innervation is done by

A

autonomic NS

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14
Q

brain stem or spinal cord autonomic neurons are termed

A

preganglionic

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15
Q

autonomic ganglion (outside the CNS) are termed

A

postganglionic

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16
Q

3 famous motor neurons

A

purkinje, pyramidal, alpha motor neurons

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17
Q

where are purkinje motor neurons located?

A

cerebellum (damage would cause tremors, ataxia)

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18
Q

where are pyramidal motor neurons located?

A

cerebrum, upper motor neurons

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19
Q

where are alpha motor neurons located?

A

brainstem, spinal cord, lower motor neurons (damage would cause twitching, vasiculation)

20
Q

what are interneurons?

A

inhibitory usually between 2 neurons*

21
Q

largest neurons in the cerebellum?

A

purkinje neurons

22
Q

**upper motor neurons are made of ___ found in the ____

A

pyramidal neurons* in the cerebral cortex (cereBRAL, pyramiDAL)

23
Q

where are alpha motor neurons found?

A

lower motor neurons (ventral horn of spinal cord, to skeletal muscles, in brainstem motor nuclei)

24
Q

where are preganglionic cell bodies located?

A

brainstem nuclei, lateral horn of spinal cord

25
where are preganglionic axons to post ganglionic neurons located?
in PNS ganglia
26
the post ganglionic sympathetic neurons to sweat glands are adrenergic or cholinergic?
cholinergic (as are the preganglionic neurons to sweat glands)
27
where are ANS sympathetic neurons located?
lateral horn T1-L2; chain and collateral ganglia
28
where are ANS parasympathetics located?
cranial (brainstem nuclei, ganglia) and sacral (lateral horn S2-S4, ganglia in organs)
29
glial to neuron ratio
10:1
30
*protein that all types of astrocytes have (astrocyte marker)
Glial Fibrillary Acidic Pritein (GFAP)- an intermediate filament; amt. increases during reactivity
31
function of astrocytes
scavenge for ions, neurotransmitters, GLIAL SCAR, tell endothelial cells to form BBB, produce cytokines
32
protoplasmic astrocytes are made of ____ matter; fibrous astrocytes are made of ____ matter
grey; white; both types form vascular end feet
33
describe the structural characteristics of oligodendrocytes
few processes, pycnotic nucleus, near neurons, no basal lamina, myelinate MANY axons
34
origin of microglia
bone marrow
35
where are microglia found?
grey matter, white matter, spines on cell body and processes
36
microglia produce cytokines and express
MHC-I and MHC-II
37
what is the neuropil?
substance between neurons; collection of neuronal and glial processes
38
what cells form the brain-CSF barrier?
ependymal cells (have cilia to move CSF)
39
what do ependymal cells line?
ventricles of the brain and central spinal cord canal
40
function of tight junctions
to block reactive substances from entering the space
41
*what is the BBB composed of? (the actual barrier)
capillary endothelial cell TIGHT JUNCTIONS
42
where is the BBB absent?
circumventricular organs like the pineal gland
43
what forms the blood-CSF barrier?
pia, ependymal, blood vessels
44
which layer of meninges is adherent to the brain?
pia mater
45
what makes the meninges?
fibroblasts of pia, arachnoid, and dura mater
46
name the spaces where hematomas occur
epidural space, subdural space, subarachnoid space