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AUC Med > Histology > Flashcards

Histology Flashcards

1
Q

What is parenchyma?

A

Secretory epithelial cells

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2
Q

What is the stroma?

A

Connective tissue of glands that divides them into lobes and lobules

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3
Q

The shape of secretory epithelium may be ___?

A

Tubular or acinar/alevolar

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4
Q

Define exocrine glands

A

Secrete into ducts connected to a surface

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5
Q

Define endocrine glands

A

Secrete directly into blood vessels

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6
Q

Define merocrine secretion and give example

A

exocytose vessicles, serrous glands (exocrine pancreas, salivary, goblet cells)

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7
Q

Define apocrine secretion and give an example

A

Apical portion of gland is shed with lipid secretion (mammary gland, prostate)

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8
Q

Define holocrine secretion

A

Cell undergoes apoptosis, releasing secretory contents (sebaceous glands)

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9
Q

List six major functions of saliva

A

Buffering, breakdown (amylase lipase), bacteria control (lysozyme, IgA, lactoferrin), moisture, mineralization (Ca2+, K+), Protective film (protein)

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10
Q

What are the functions of striatedd ducts?

A

Production of bicarbonate, reabsorption of sodium chloride

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11
Q

What are the 3 types of secretion

A

Serous, mucous, mixed

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12
Q

Describe serous secretion. What gland has serous acini?

A

Proteinaceous, watery consistency, parotid gland

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13
Q

Describe mucous secretion. Which gland has mucous acini?

A

Glycoproteinaceous, complex polysaccharides, viscous. Sublingual gland.

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14
Q

What secretory gland of the upper GI system has mixed acini?

A

Submandibular gland, mixed acini result in serrous demilunes

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15
Q

Describe striated ducts

A

Pizza shaped epithelial cells with basal plasma membrane infoldings and mitochondria

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16
Q

Describe the difference between serous and mucous acini?

A

Serous acini- the cytoplasm is basophilic basally (RNA), eosinophlic apically (zymogen), small lumen, round nuclei, intercellular cannaliculi.
Mucous acini- flattened nuclei on basal side, lighter staining, bigger lumen.

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17
Q

What cells surround secretory acini? What can they be stained with?

A

Myoepithelial cells, F-actin stain

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18
Q

What are the 4 types of papillae found on the tongue?

A

Foliate, fungiform, filiform, circumvallate

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19
Q

Which papillae of the tongue do not have taste buds?

A

Filiform papillae

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20
Q

What are von Ebner’s glands?

A

Serrous secreting glands in the furrow of circumvalate papilla

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21
Q

What are the 3 layers of the tongue?

A

Stratified squamous epithelium, connective tissue, skeletal muscle (oblique and longitudinal)

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22
Q

Describe taste buds

A

Onion shape with sensory and supporting cell “petals,” taste pore at surface, basal stem cells, afferent nerve terminals on sensory cells

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23
Q

Describe the structure of the teeth

A

Enamel, dentin, odontoblasts, pulp chamber, root canal, periodontal ligament, alveolar bone

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24
Q

What cells produce enamel? What happens to them?

A

Ameloblasts produce enamel towards the odontoblasts. They die when the cell breaks the surface.

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25
Q

Name and describe the layers of the GI tract

A

Mucosa (epithelium, lamina propria, muscularis mucosa), submucosa (DICT), muscularis externa (smooth muscle bilayer), serosa (mesothelium) OR Adventitia (DICT)

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26
Q

Describe the muscularis externa in general

A

Inner circular smooth muscle, outer longitudinal smooth muscle

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27
Q

Where is Auerbach’s plexus?

A

The myenteric plexus- between the layers of the muscularis externa

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28
Q

Where is Meissner’s plexus?

A

Submucosa- allows the muscularis mucosa to contract independently of the muscularis externa.

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29
Q

Dscribe the muscularis externa in the esophagus

A

Upper 1/3 = skeletal muscle,
Middle 1/3 = skeletal and smooth muscle
Lower 1/3 = smooth muscle

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30
Q

What type of epithelium does the stomach have?

A

Simple columnar epithelium

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31
Q

What type of epithelium does the esophagus have?

A

Stratified squamous non-keratinized epithelium

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32
Q

Where are cardiac glands and what do they do?

A

In the stomach near the esophageal orifice, they secrete bicarbonate rich mucous

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33
Q

What is the difference between exocrine and endocrine glands?

A

Exocrine glands have ducts with a lumen which travel to the apical side of the cell to discharge secretions, endocrine glands secrete on the basal side of the cell directly into the bloodstream (hormones) and thus have no lumen.

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34
Q

Name and give an example of the four types of exocrine glands

A

1) Simple tubular- luminar surface, i.e. intestinal glands
2) Simple acinar (alveoli)- sebaceous glands
3) Compund tubulo-acinar- salivary
4) Compound acinar- pancreas

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35
Q

Name and describe the 6 types of ducts

A

1) Acinus: secrete mucins, proteins, and enzymes, transport Na+, Cl-, H2O, IgA.
2) Intercolated (transport)
3) Striated: Prominent epithelial basal membrane folding to increase surface area for pumps in plasma membrane, prominent mitochondria, secrete bicarbonate, reabsorb Na+, Cl-, much larger than intercolated ducts
4-6) Intralobular, Interlobular, Lobular

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36
Q

Describe the parotid gland

A

located anterior and posterior to the ear, have long intercollated ducts, contain serous acinus (basophilic, nuclei near center of pie wedge, secrete protein, watery consistency)

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37
Q

Describe the sublingual gland

A

Have short ducts, contain mucous actinus (lighter staining, peripheral nuclei, secrete glycoproteins, mucus polysaccharides, viscous gel)

38
Q

Describe the submandibular gland

A

Have prominent striated ducts, contain serous AND mucous acinus, serous demilunes from preparation

39
Q

Describe fungiform papilla

A

mushroom shaped and have dorsal taste buds. CC- Riley-Day Synrome, smooth tongue

40
Q

If there is a ganglia within the wall of an organ, it must be part of what nervous system?

A

Parasympathetic

41
Q

Describe GERD and Barret’s Esophagus

A

GERD is the backflow of acid from the stomach, through the pyloric sphincter into the esophagus causing burning and pain. In Barret’s Esophagus, the esophagus tissue becomes damaged from chronic exposure to stomach acid and undergoes metaplasia, becoming more like simple columnar epithelium of the stomach.

42
Q

What dye does mucous stain with?

A

PAS

43
Q

What 4 types of cells make up the gastric glands?

A

Chief cells, parietal cells, mucus neck cells, enteroendocrine cells

44
Q

Describe parietal cells of gastric glands

A
  • secrete HCl, intrinsic factor (required for Vitamin B12 absorption)
  • between chief cells, very eosinophilic, large cells
  • many mitochondria, no granules
  • secretory canaliculus, internal microvilli
45
Q

Describe chief cells of the stomach

A
  • low columnar with zymogen granules (pepsinogen and lipase)

- base of cell basophilic

46
Q

Describe mucous neck cells of the gastric glands

A
  • near gastric pit

- numerous secretory granules of mucin

47
Q

Describe enteroendocrine cells of gastrin glands

A

-produce hormones: serotonin; gastrin

48
Q

In what 5 ways is the SA of the small intestine increased?

A

(1) length of small intestine
(2) plicae circulares: (valves of Kerckring), semicircular folds of submucosa
(3) intestinal villi: finger-like projections of epithelium
(4) microvilli: increase surface area of epithelial cells
(5) glycocalyx: Glycoproteins (enterokinases) projecting from microvilli

49
Q

What 2 types of cells are found in the mucous membrane of the intestine?

A

(1) Columnar absorptive cells
- brush border and glycocalyx
- junctional complexes
- role in absorption and digestion
(2) Goblet cells
- apical region distended with mucigen droplets

50
Q

What and where are Brunner’s glands?

A

Submucosa of duodenum
compound tubular glands, produce mucus with an alkaline, bicarbonate content
- ducts penetrate muscularis mucosae and empty into the crypts of Lieberkuhm

51
Q

Describe paneth cells

A

In lamina propria- secrete lysozyme, large, apical, eosinophilic granules, basal ER.

52
Q

Describe enteroendocrine cells of intestines

A

Secrete Secretin and Cholecystokinin (CCK)

towards basal lamina

53
Q

What and where are Peyer’s patches?

A

groups of lymphatic nodules

  • in lamina propria and submucosa of ileum
  • local source of lymphocytes (no lymph filtration by these nodules)
54
Q

In an autimmune disease which targets the gastric mucosa, resulting in a lack of intrinsic factor, which cell type is most affected?

A

Parietal cells

55
Q

The colon has no villi, but what cell type is abundant?

A

Goblet cells

56
Q

What is the exocrine function of the liver?

A

To secrete bile into the duodenum

57
Q

From where does the liver receive it’s blood?

A
  • receives venous blood from intestine via portal vein - receives arterial blood via hepatic
    artery
58
Q

List the 5 functions of the liver

A

(1) absorbed products of digestion are metabolized or transformed & returned to the
blood
(2) toxic substances in the blood are degraded or detoxified
(3) bile is produced for release into the intestine where it plays a role in digestion of
lipids
(4) the protein components of blood plasma is produced
(5) carbohydrates are stored as glycogen & released as glucose - maintains blood
glucose

59
Q

Each portal area of the liver contains what 3/4 things?

A

A branch of the portal vein, a branch of the hepatic artery, a bile duct, sometimes a lymphatic vessel is also seen

60
Q

The portal vein, hepatic artery and bile duct enter the liver where?

A

On the inferior surface at the porta hepatis

61
Q

Where do the portal vein, hepatic artery, and bile duct travel?

A

terminal branches of artery, vein and bile duct leave the portal area and feed sinusoids

  • blood leaves the sinusoids at the central vein
  • the central vein passes to a collecting vein – to the hepatic veins – to the vena cava
62
Q

What and where are Kupffner cells?

A

Situated on or between endothelial cells in sinusoids of liver

  • highly phagocytic, lysosomal activity (destroy bacteria, erythrocytes)
  • surface folds and processes
  • support for these cells is by fine reticular fibres
63
Q

What s another name for the perisinusoidal space?

A

Space of Disse

64
Q

What is the function of hepatocytes?

A

Store carbohydrates as glycogen and synthesize plasma proteins

65
Q

Cells secrete intrinsic factor (B12 breakdown) and HCL

A

Parietal Cells

66
Q

The secretion granules on the apical side of serrous acini are:

A

Amylase and lipase

67
Q

The Crypts of Lieberkuhn are contained in which layer of the GI tract?

A

Mucosa

68
Q

The Brunner’s glands are contained in which layer of the GI tract?

A

Submucosa

69
Q

Meissner’s plexus inner cares which layer of the GI tract?

A

Muscularis mucosa

70
Q

This hormone is produced by the endothelial cells of the gastric mucosa and stimulates HCL secretion

A

Gastrin

71
Q

Which GI tract cell type secretes lysozymes into the intestinal lumen?

A

Paneth cells

72
Q

Pepsinogen and lipase are secreted into the stomach by which cell type?

A

Chief cells

73
Q

Gastric enteroendocrine cells secrete which hormone into the gastric mucosa?

A

Gastrin

74
Q

Intestinal enteroendocrine cells secrete which two substances into the mucosa?

A

Cholecystokinin and secretin

75
Q

CCK and secretin are produced by which cell type in the GI tract?

A

Intestinal enteroendocrine cells

76
Q

The walls of the duodenum are made up of what structures?

A 
From outside:
Longitudinal muscularis externa
Auerbach’s plexus
Circular muscularis externa
Brunner’s glands
Muscularis mucosa
Crypts of Lieberkuhn
Enterocytes
77
Q

Which section of the small intestine contains lots of mucous secreting glands in the submucosa? What are these glands called?

A

Duodenum, Brunner’s glands

78
Q

What are collections of lymphocytes in the submucosa and mucosa of the ileum?

A

Peyer’s patches

79
Q

Smooth muscle contraction in the gallbladder is regulated by:

A

Cholecystokinin (CCK)

80
Q

Collections of lighter staining endocrine cells in the pancreas are called:

A

Islets of Langerhans

81
Q

The outer edges of the Islets of Langerhand contain what two types of cell?

A

Alpha and delta

82
Q

The inner portion of the Islets of Langerhans contain what type of cells?

A

Beta

83
Q

Alpha cells of the Islets of Langerhans secrete what hormone?

A

Glucagon

84
Q

Beta cells of the Islets of Langerhans secrete what hormone?

A

Insulin

85
Q

Delta cells of the Islets of Langerhans secrete what hormone?

A

Somatostatin

86
Q

Pancreatic juice, secreted by serous acini of the pancreas, contains what enzymes?

A 
Trypsinogen
Chymotrypsinogen
Carboxypeptidase
Lipase
Nuclease
Amylase
87
Q

What hormone regulates serous acini in the pancreas?

A

Cholecystokinin (CCK) from intestinal enteroendocrine cells

88
Q

What type of ducts does the pancreas contain?

A

Intercollated

89
Q

Intercollated ducts in the pancreas secrete what chemical?

A

Bicarbonate

90
Q

What hormone triggers the release of bicarbonate from epithelial cells in the intercollated ducts of the pancreas?

A

Secretin from intestinal enteroendocrine cells

AUC Med (12 decks)

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