histology 2- cartilage

Question 1

origin of chondroblast

Answer 1

mesenchyme cells

Question 2

cartilage composition

Answer 2

cells and ECM

Question 3

cartilage

Answer 3

composition
perichondrium
avascular

Question 4

cartilage cells

Answer 4

chondroblast

chondocytes

Question 5

chondroblast

Answer 5

on outside surface of tissue, produce ECM, not completely surrounded by ECM yet

Question 6

chondrocytes

Answer 6

also produce matrix, also maintain it. on inside of cartilage, completely surrounded by ECM

Question 7

when do chondroblast turn into chondrocytes

Answer 7

when ECM completely surrounds the cell

Question 8

what is space called that cells sit inside after surrounded by ECM

Answer 8

lacunae

Question 9

characteristics of cartilage ECM

Answer 9

1. 95% water
2. Rich in GAG’s and proteoglycans
3. allows for withstanding forces, resilent

Question 10

dense CT covering most cartilage

Answer 10

perichondrium

Question 11

perichondrium

Answer 11

contains blood vessels, nerves, chondrogenic cells, type 1 cartilage, important in growth and maintenance of cartilage

Question 12

chondrogenic cells

Answer 12

found in perichondrium, produce chondroblast

Question 13

what limits diffusion thus limiting growth in cartilage

Answer 13

avascular

Question 14

2 mechanisms of growth

Answer 14

appositional growth

interstital growth

Question 15

appositional growth

Answer 15

growth by additional to existing surface. generation of new chondroblast, adding in addiontal ECM

Question 16

interstital growth

Answer 16

growth by internal expansion. proliferation of chondrocytes and formation of isogenous groups. have to start producing ECM in between cells which makes tissue grow

Question 17

isogenous groups

Answer 17

cluster of chondrocytes in lacunae, undergo mitosis

Question 18

3 types of cartilage

Answer 18

1. hyalin
2. elastic
3. fibrocartilage

Question 19

hyalin cartilage ECM composition

Answer 19

75% water, proteoglycans, Hyaluaric acid, type 2 collagen!

Question 20

what is most common cartilage in human body

Answer 20

hyalin cartilage

Question 21

location of hyalin cartilage

Answer 21

nose, larynx, tracheal cartialge, fetal bone models, articular surfaces

Question 22

does hyalin have perichondrium

Answer 22

yes

Question 23

appearance of hyalin cartilage

Answer 23

fresh discect- bluish-white and translucent

matrix is basophilic- can’t see collagen type 2 fibers

Question 24

shape of chondrocytes compared to chondroblast

Answer 24

cytes are more rounded.

Question 25

hyalin cartilage is more ____philic

Answer 25

basophilic

Question 26

perichondrium is more _____philic

Answer 26

eosinphilic

Question 27

what indicates growing cartilage, newly synthesized cells

Answer 27

isogenous groups

Question 28

right around isogenous groups stain _____

Answer 28

darker

Question 29

what is stained lighter around isogenous groups, darker?

Answer 29

interterritorial matrix, territorial matrix.

Question 30

interterritorial matrix has lots of ______

Answer 30

collagen fibers

Question 31

territorial ECM richer in what

Answer 31

GAG's, not as much collagen

Question 32

what binds to GAG's to give territorial darker color

Answer 32

hematoxylin

Question 33

elastic cartilage ECM composition

Answer 33

essentially the same as hyalin cartilage. type 2 cartilage plus elastic fibers.

Question 34

location of elastic cartilage

Answer 34

auricle, auditory tube, auditory canal, epiglottis

Question 35

appearance of elastic cartilage newly dissection

Answer 35

yellow in color cuz of elastic cartilage

Question 36

how to differentiate elastic cartilage

Answer 36

higher ratio of chondroytes to matrix. (ALOT MORE CELLS) | fewer cells per isogenous groups (2-3)

Question 37

fibrocartilage ECM composition

Answer 37

type 1 collagen | less proteoglycans than other other cartilages.

Question 38

location of fibrocartilage

Answer 38

intervertebral disc pubic symphysis major tendon-bone anchorages

Question 39

does fibrocartilage have perichondrium

Answer 39

no

Question 40

appearance of fibrocartilage

Answer 40

tissue intermediates between dense regular connective tissue and hyalin cartilage. chondrocytes arragned in long rows separated by coarse collage fibers.

Question 41

matrix of fibrocartilage is more ______

Answer 41

acidophilic

Question 42

what does lots of type 1 collagen help with

Answer 42

high tensile strength, under goes lots of pressure. can handle lots of pressures