Histological Feautres of stroke

Question 1

How soon after stroke can imaging pick up ischemic changes?

Answer 1

• CT: 6-24 hrs
• MRI (diffusion-weighted): 3-30 mins

Question 2

What histological changes will occur 12 -24 hrs after stroke?

Answer 2

• Eosinophilic cytoplasm
• Pykonotic nuclei (red nucleus due to pyknosis or degradation of the nucleus and loss of Nissl bodies which are normally stained blue [basophilic])

Question 3

What histological changes will occur 24-72 hrs after stroke?

Answer 3

• Necrosis
• Neutrophils

Question 4

What histological changes will occur 3 -5 days after a stroke?

Answer 4

Macrophages will appear (microglia)

Question 5

What histological changes will occur 1 - 2 weeks after a stroke?

Answer 5

• Reactive gliosis (astrocytes)
• Vascular proliferation

Question 6

What will be seen after 2 weeks?

Answer 6

Glial scar