Cerebral perfusion, brain anatomy and reflexes Flashcards
Cerebral perfusion is primarily driven by what?
PCO2
At what oxygen pressure will O2 influence CPP?
Severe hypoxemia < 50 mmHg
What is the cerebral perfusion pressure equal to (what is the equation)?
CPP = MAP - ICP
What are the signs of Increased ICP (cushing reflex)?
- Hypertension
- Bradycardia
- Respiratory depression
- Wide pulse pressure
When does CPP not become proportional to PCO2?
When PCO2 is > 90 mmHg
What symptoms will an ACA-MCA watershed infarct cause?
Proximal upper and lower extremity weakness (“man-in-a-barrel” syndrome)
What symptoms will a PCA-MCA watershed infarct give?
Higher-order visual dysfunction
How is CSF drained?
Into cerebral veins from arachnoid granulations
A venous sinus will present with what?
- Additionally what risk factors may they have
Signs/symptoms of increased ICP
- Headache
- Seizures
- Papilloedema
- Focal neurological deficits
Risk factors are hypercoagulable states e.g:
- OCP use
- Pregnant
- Factor V Leiden
Where is the nucleus of CNXI found?
Spinal cord
What is the pineal gland responsible for?
- Melatonin secretion
- Circadian rhythms
What are the superior colliculi responsible for?
Direct eye movemtns tostimuli (noise/movements) or objects of interest
What are the inferior colliculi responsible for?
Auditory
Name the vagal nuclei
- Nucleus tractus solitarus
- Nucleus ambiguus
- Dorsal motor nucleus
What is the function of the nucleus tractus solitarus?
- Visceral sensory info (taste, baroreceptors, gut distension)
- May play a role in vomitinfg
- CN VII, IX, X
What is the function of the nucleus ambigus?
- Motor innervation of pharynx, larynx, upper esophagus (e.g swallowing, palate elevation)
- CN IX, X, XI (cranial portion)