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High Yield Comlex > High yield Immunology > Flashcards

High yield Immunology Flashcards

1
Q

Rapid, nonspecific response with no memory, mediated by macrophages, dendritic cells, NK cells, neutrophils and complement

A

Innate immunity

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2
Q

Ig that protects mucus membranes and can dimerize

A

IgA

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2
Q

Complement protein that participates in opsonization along with IgG

A

C3B

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3
Q

Complement protein that serves as a chemoattractant for neutrophils

A

C5A (IL-8 also does this but is not a complement protein)

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3
Q

Complement proteins involved in Membrane Attack Complex

A

C5b-C9 (especially Neisseria inf)

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4
Q

Pyrogenic cytokines

A

IL-1, IL-6, TNF alpha

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4
Q

Cytokine that modulates and shuts off immune response

A

IL-10

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5
Q

X linked recessive disease in which there is no B cell maturation. Recurrent bacterial infections after 6 months. Decreased B cells and decreased Ig’s

A

Bruton’s Agammaglobulinemia

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5
Q

22q11 deletion causing recurrent viral and fungal infections, congenital heart defects, tetany due to hypocalcemia

A

Thymic aplasia (Di George)

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6
Q

Disease in which there is a defective IL-2 receptor. Susceptible to bacterial, viral, fungal and protozoan infections. Absence of germinal centers and B cells. Sx: diarrhea, thrush, failure to thrive

A

SCID

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6
Q

Defects in DNA repair enzymes, cerebellar defects, spider angiomas, IgA deficiency

A

Ataxia telangiectasia

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7
Q

Defect in CD-40 which is responsible for class switching. Severe pyogenic infections early in life

A

Hyper IgM syndrome

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7
Q

Characterized by a decrease in NADPH oxidase, leading to absent respiratory burst. Susceptible to catalase positive bacteria (staph A, E. coli, Aspergillus)

A

Chronic granulomatous disease

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8
Q

Response is slow on 1st exposure and rapid on subsequent exposures. Mediated by antibodies, T and B cells

A

Adaptive immunity

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9
Q

MHC I (HLA A,B,C) binds to CD8 and is found on

A

all nucleated cells

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10
Q

MCH II (HLA-DP, DR, DQ) binds to CD4 and is found on

A

Antigen presenting cells

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11
Q

HLA A3 is associated with

A

Hemochromatosis

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12
Q

HLA B27 is associated with these 4 things

A

ankylosing spondylitis, Reiter’s syndrome, IBD, psoriasis

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13
Q

HLA DQ2/DQ8 is assoc with

A

Celiac disease

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14
Q

HLA DR-2 is assoc with these 3 things

A

MS, SLE, Goodpasture’s

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15
Q

HLA DR-3 is assoc with these 2 things

A

DM type 1, Grave’s disease

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16
Q

HLA DR-4 is assoc with these 2 things

A

DM type 1, RA

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17
Q

HLA DR-5 is assoc with these 2 things

A

Hashimoto’s thyroiditis and pernicious anemia

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18
Q

This portion of the antibody binds complement and determines the isotype

A

Fc portion

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19
Class switching is mediated by this cytokine
CD40
20
Ig that crosses the placenta and patricipates in opsonization
IgG
21
Guillian Baree from an influenza shot is considered what type of Hypersensitivity?
IV because it occurs days later
22
type of cell that secretes IL-1 to promote T cell activity
Macrophage
23
which subset of T helper cells secrete IL-2?
TH1
24
What does IgE do?
causes mast cells and basophils to release histamine when triggered by antigen
25
which interleukin promotes IgA and induces differentiation of eosinophils?
IL-5
26
cytokine causing cachexia
TNF alpha
27
which interleukin promotes IgG and IgE?
IL-4
28
class of bacteria susceptible to complement mediated lysis
Gram negative
29
complement proteins active against viruses?
C1-4
30
type of rejection that happens due to preformed antibodies in host reacting against graft antigens
Hyperacute (minutes to hours)
31
type of rejection that happens due to activation of previously sensitized T cells
accelerated (hours to days)
32
type of rejection that happens because of T cell activation, differentiation and antibody production
Acute (days to weeks)
33
type of rejection that happens because of immune complex deposition with subacute cytotoxicity
Chronic (months to years)
34
disease associated with antibasement membrane antibodies
goodpastures
35
disease associated with anti-centromere antibodies
CREST syndrome
36
Drug induced lupus is associated with what autoantibody
anti-histone
37
Myositis is associated with what autoantibody
anti-Jo1
38
Antimicrosomal antibodies are associated with what disease?
Hashimotos thyroiditis
39
AKA rheumatoid factor
anti-IgG
40
anti-dsDNA and anti-smith are highly specific for
SLE
41
Antimitochondrial antbodies are associated with what disease?
Primary Biliary cirrhosis
42
systemic sclerosis is associated with what autoantibody?
anti-Scl-70 (topoisomerase)
43
Autoantibodies for Sjrogens syndrome
Anti-SSa and anti-SSb
44
autoantibodies found in Wegener granulomatosis
C-ANCA (cytoplasmic pattern antineutrophil cytoplasmic antibodies)
45
Diseases associated with p-ANCA (perinuclear pattern antineutrophil antibodies) (3)
Microscopic polyangiitis, Polyarteritis nodosa, Churg Strauss
46
characteristics of Bruton's X linked Agammaglobulinemia
mutation in Btk (bruton tyrosine kinase) causing B cell deficiency causing recurrent respiratory tract infections in young boys > 6 mo (staph, strep, haemophilus, Giardia)
47
characteristics of DiGeorge syndrome
failure of 3rd and 4th pharyngeal arches causing thymic aplasia which means no T cells so there are frequent viral and fungal infections, hypocalcemia due to no parathyroid which causes tetany. Also congenital defects of heart and aorta.
48
characteristics of SCID
can be caused by adenosine deaminase deficiency or mutation of cytokine receptor IL-7 causing defective B and T cells. Thus susceptible to fungal, viral, parasitic and bacterial infections.
49
characteristics of ataxia telangiectasia
IgA deficiency, cerebellar dysfunction, telangiectasias especially in eyes
50
characteristics of Chronic granulomatous disease
deficiency of NADPH oxidase leading to impaired respiratory burst leading to increased susceptibility to catalase positive organisms.
51
characteristics of hyper-IgM syndrome
defect in CD 40 leading to no class switching
52
characteristics of Chediak HIgashi syndrome
microtubule defect causing impaired phagocytosis, partial albinism, peripheral neuopathy
53
characteristics of Job (hyper IgE syndrome)
failure of neutrophil chemotaxis, ezcema, elevated IgE, noninflammed staph abcess
54
characteristics of Wiskott Aldrich syndrome
increased IgA, normal IgE, low IgM, recurrent infections, thrombocytopenia, ezcema

High Yield Comlex (9 decks)

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