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High Yield Comlex > High yield Immunology > Flashcards

High yield Immunology Flashcards

1
Q

Rapid, nonspecific response with no memory, mediated by macrophages, dendritic cells, NK cells, neutrophils and complement

A

Innate immunity

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2
Q

Ig that protects mucus membranes and can dimerize

A

IgA

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2
Q

Complement protein that participates in opsonization along with IgG

A

C3B

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3
Q

Complement protein that serves as a chemoattractant for neutrophils

A

C5A (IL-8 also does this but is not a complement protein)

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3
Q

Complement proteins involved in Membrane Attack Complex

A

C5b-C9 (especially Neisseria inf)

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4
Q

Pyrogenic cytokines

A

IL-1, IL-6, TNF alpha

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4
Q

Cytokine that modulates and shuts off immune response

A

IL-10

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5
Q

X linked recessive disease in which there is no B cell maturation. Recurrent bacterial infections after 6 months. Decreased B cells and decreased Ig’s

A

Bruton’s Agammaglobulinemia

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5
Q

22q11 deletion causing recurrent viral and fungal infections, congenital heart defects, tetany due to hypocalcemia

A

Thymic aplasia (Di George)

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6
Q

Disease in which there is a defective IL-2 receptor. Susceptible to bacterial, viral, fungal and protozoan infections. Absence of germinal centers and B cells. Sx: diarrhea, thrush, failure to thrive

A

SCID

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6
Q

Defects in DNA repair enzymes, cerebellar defects, spider angiomas, IgA deficiency

A

Ataxia telangiectasia

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7
Q

Defect in CD-40 which is responsible for class switching. Severe pyogenic infections early in life

A

Hyper IgM syndrome

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7
Q

Characterized by a decrease in NADPH oxidase, leading to absent respiratory burst. Susceptible to catalase positive bacteria (staph A, E. coli, Aspergillus)

A

Chronic granulomatous disease

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8
Q

Response is slow on 1st exposure and rapid on subsequent exposures. Mediated by antibodies, T and B cells

A

Adaptive immunity

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9
Q

MHC I (HLA A,B,C) binds to CD8 and is found on

A

all nucleated cells

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10
Q

MCH II (HLA-DP, DR, DQ) binds to CD4 and is found on

A

Antigen presenting cells

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11
Q

HLA A3 is associated with

A

Hemochromatosis

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12
Q

HLA B27 is associated with these 4 things

A

ankylosing spondylitis, Reiter’s syndrome, IBD, psoriasis

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13
Q

HLA DQ2/DQ8 is assoc with

A

Celiac disease

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14
Q

HLA DR-2 is assoc with these 3 things

A

MS, SLE, Goodpasture’s

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15
Q

HLA DR-3 is assoc with these 2 things

A

DM type 1, Grave’s disease

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16
Q

HLA DR-4 is assoc with these 2 things

A

DM type 1, RA

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17
Q

HLA DR-5 is assoc with these 2 things

A

Hashimoto’s thyroiditis and pernicious anemia

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18
Q

This portion of the antibody binds complement and determines the isotype

A

Fc portion

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19
Q

Class switching is mediated by this cytokine

A

CD40

20
Q

Ig that crosses the placenta and patricipates in opsonization

A

IgG

21
Q

Guillian Baree from an influenza shot is considered what type of Hypersensitivity?

A

IV because it occurs days later

22
Q

type of cell that secretes IL-1 to promote T cell activity

A

Macrophage

23
Q

which subset of T helper cells secrete IL-2?

A

TH1

24
Q

What does IgE do?

A

causes mast cells and basophils to release histamine when triggered by antigen

25
Q

which interleukin promotes IgA and induces differentiation of eosinophils?

A

IL-5

26
Q

cytokine causing cachexia

A

TNF alpha

27
Q

which interleukin promotes IgG and IgE?

A

IL-4

28
Q

class of bacteria susceptible to complement mediated lysis

A

Gram negative

29
Q

complement proteins active against viruses?

A

C1-4

30
Q

type of rejection that happens due to preformed antibodies in host reacting against graft antigens

A

Hyperacute (minutes to hours)

31
Q

type of rejection that happens due to activation of previously sensitized T cells

A

accelerated (hours to days)

32
Q

type of rejection that happens because of T cell activation, differentiation and antibody production

A

Acute (days to weeks)

33
Q

type of rejection that happens because of immune complex deposition with subacute cytotoxicity

A

Chronic (months to years)

34
Q

disease associated with antibasement membrane antibodies

A

goodpastures

35
Q

disease associated with anti-centromere antibodies

A

CREST syndrome

36
Q

Drug induced lupus is associated with what autoantibody

A

anti-histone

37
Q

Myositis is associated with what autoantibody

A

anti-Jo1

38
Q

Antimicrosomal antibodies are associated with what disease?

A

Hashimotos thyroiditis

39
Q

AKA rheumatoid factor

A

anti-IgG

40
Q

anti-dsDNA and anti-smith are highly specific for

A

SLE

41
Q

Antimitochondrial antbodies are associated with what disease?

A

Primary Biliary cirrhosis

42
Q

systemic sclerosis is associated with what autoantibody?

A

anti-Scl-70 (topoisomerase)

43
Q

Autoantibodies for Sjrogens syndrome

A

Anti-SSa and anti-SSb

44
Q

autoantibodies found in Wegener granulomatosis

A

C-ANCA (cytoplasmic pattern antineutrophil cytoplasmic antibodies)

45
Q

Diseases associated with p-ANCA (perinuclear pattern antineutrophil antibodies) (3)

A

Microscopic polyangiitis, Polyarteritis nodosa, Churg Strauss

46
Q

characteristics of Bruton’s X linked Agammaglobulinemia

A

mutation in Btk (bruton tyrosine kinase) causing B cell deficiency causing recurrent respiratory tract infections in young boys > 6 mo (staph, strep, haemophilus, Giardia)

47
Q

characteristics of DiGeorge syndrome

A

failure of 3rd and 4th pharyngeal arches causing thymic aplasia which means no T cells so there are frequent viral and fungal infections, hypocalcemia due to no parathyroid which causes tetany. Also congenital defects of heart and aorta.

48
Q

characteristics of SCID

A

can be caused by adenosine deaminase deficiency or mutation of cytokine receptor IL-7 causing defective B and T cells. Thus susceptible to fungal, viral, parasitic and bacterial infections.

49
Q

characteristics of ataxia telangiectasia

A

IgA deficiency, cerebellar dysfunction, telangiectasias especially in eyes

50
Q

characteristics of Chronic granulomatous disease

A

deficiency of NADPH oxidase leading to impaired respiratory burst leading to increased susceptibility to catalase positive organisms.

51
Q

characteristics of hyper-IgM syndrome

A

defect in CD 40 leading to no class switching

52
Q

characteristics of Chediak HIgashi syndrome

A

microtubule defect causing impaired phagocytosis, partial albinism, peripheral neuopathy

53
Q

characteristics of Job (hyper IgE syndrome)

A

failure of neutrophil chemotaxis, ezcema, elevated IgE, noninflammed staph abcess

54
Q

characteristics of Wiskott Aldrich syndrome

A

increased IgA, normal IgE, low IgM, recurrent infections, thrombocytopenia, ezcema

High Yield Comlex (9 decks)

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