High grade lymphoma

Question 1

What is Burkitt’s lymphoma?

Answer 1

High grade B cell lymphoma

Question 2

What are the types of Burkitt’s lymphoma?

Answer 2

Endemic
Sporadic

Question 3

What is endemic Burkitt’s lymphoma associated with?

Answer 3

Involves Maxilla or mandible
Strongly associated with EBV

Question 4

What is the most common tumour in sporadic Burkitt’s lymphoma?

Answer 4

Abdominal tumours

Question 5

What is sporadic Burkitt’s lymphoma associated with?

Answer 5

HIV

Question 6

What genetics are involved in Burkitt’s lymphoma?

Answer 6

c-myc gene, t(8;14)

Question 7

What is the appearance on biopsy in Burkitt’s?

Answer 7

Starry sky appearance

Question 8

What is a common complication with Burkitt’s lymphoma?

Answer 8

Tumour lysis syndrome

Question 9

What is Hodgkin lymphoma characterised by?

Answer 9

Reed-Sternberg cells

Question 10

What are risk factors for Hodgkin’s lymphoma?

Answer 10

HIV
EBV

Question 11

What are the common features of Hodgkin’s?

Answer 11

Lymphadenopathy - 75%
- cervical > axillary >inguinal
B symptoms - 25%
Alcohol induced lymph node pain is classic but rare

Question 12

What is seen on bloods in Hodgkin’s?

Answer 12

Normocytic amaemia
Eosinophilia - due to cytokine release
Raised LDH

Question 13

What is seen on lymph node biopsy in Hodgkin’s?

Answer 13

Reed-Sternberg cells - Owl’s eye appearance

Question 14

What is the most common type of Hodgkin’s lymphoma?

Answer 14

Nodular sclerosing

Question 15

What subtype of Hodgkin’s has the best prognosis?

Answer 15

Lymphocyte predominant

Question 16

What subtype of Hodgkin’s has the worst prognosis?

Answer 16

Lymphocyte deplete

Question 17

What implies a poor prognosis in Hodgkin’s?

Answer 17

B symptoms

Question 18

What is the management of Hodgkin’s?

Answer 18

BEACOPP - intensive, better remission rate
ABVD - less intense