AML and APML Flashcards
1
Q
What are the features of AML?
A
Anaemia
Neutropenia
Thrombocytopenia
Splenomegaly
Bone pain
2
Q
What are poor prognostic indicators in AML?
A
> 60yo
20% blasts post cycle 1 chemo
3
Q
What genetics are associated with poor prognosis in AML?
A
Deletion chromosome 5 or 7
4
Q
What genetics are associated with APML?
A
t(15;17) - fusion of PML and RAR-alpha genes
5
Q
What is the common presentation of APML?
A
Younger, average 25yo
Auer rods on stain
DIC, thrombocytopenia
6
Q
What is the immediate management of APML?
A
ATRA - forces immature granulocytes to mature
