CML Flashcards
1
Q
What is CML strongly associated with?
A
Philadelphia chromosome t(9;22)
2
Q
How does Philadelphia chromosome cause CML?
A
Proto-oncogene from chromosome 9 fused with BCR gene on chromosome 22 causing excess tyrosine kinase activity
3
Q
What is the classic presentation on blood oil. in CML?
A
Increase in granulocytes at different stages of maturation +/- thrombocytosis
4
Q
What are the common presenting features of CML?
A
Anaemia, weight loss, sweats
Splenomegaly
5
Q
What is the first line management of CML?
A
Imatinib - TKI
6
Q
What are management options in CML?
A
Imatinib - TKI
Hydroxycarbamide
Interferon alpha
Allogenic transplant
