Genetics

Question 1

What is the Philadelphia chromosome?

Answer 1

t(9;22)

Question 2

What is the Philadelphia chromosome most associated with?

Answer 2

CML - >95% patients

Question 3

What is the result of the Philadelphia chromosome?

Answer 3

Abelson porto-oncogene moved to BCR gene –> excess tyrosine kinase activity

Question 4

When is the Philadelphia chromosome a poor prognostic indicator?

Answer 4

ALL

Question 5

What is the common genetic mutation in APML?

Answer 5

t(15;17)

Question 6

What is the common genetic mutation in. Burkitt’s lymphoma?

Answer 6

t(8;14) - MYC oncogene translocated to immunoglobulin gene

Question 7

What is the common genetic mutation in MCL?

Answer 7

t(11;14)

Question 8

What is the common genetic mutation in follicular lymphoma?

Answer 8

t(14;18)

Question 9

What genetic mutation is associated with good prognosis in CLL?

Answer 9

del 13q

Question 10

What genetic mutation is associated with poor prognosis in CLL?

Answer 10

dep 17q

Question 11

What genetic mutations are associated with AML?

Answer 11

deletion of chromosome 5 or 7

Question 12

What genetic mutation is associated with poor prognosis in ALL?

Answer 12

Philedelphia chromosome t(9;22)

Question 13

What genetic mutation is associated with good prognosis in ALL?

Answer 13

del 9p

Question 14

What is BRCA associated with?

Answer 14

Breast cancer in women
BRCA1 - ovarian cancer
BRCA2 - prostate cancer

Question 15

What gene is neuroblastoma associated with?

Answer 15

n-MYC

Question 16

What gene is follicular lymphoma associated with?

Answer 16

BCL-2
t(14;18)

Question 17

What is pancreatic cancer associated with?

Answer 17

RAS

Question 18

What is mantle cell lymphoma associated with?

Answer 18

t(11;14)
BCL-1 gene