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Toxico - Theo > Hidrocarburi > Flashcards

Hidrocarburi Flashcards

1
Q

Cum se poate face contaminarea cu hidrocarburi?

A

Digestiv
Inhalator
Prin piele

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2
Q

Ce efecte generale are intoxicatia cu hidrocarburi?

A

Inflamatie parenchim pulmonar = pneumonita chimica +/- suprainfecție bacteriană

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3
Q

Ce hidrocarburi cresc riscul de aspiratie?

A

Cele alifatice

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4
Q

Ce substante pot duce la pneumonie lipoida?

A

motorina
lubrifianti
ulei de motor

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5
Q

In ce se metabolizează hidrocarburile?

A

In compusi epoxidici

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6
Q

În cadrul intoxicatiei cu hidrocarburi, ce compusi sunt responsabili de necroza hepatica?

A

Compusii epoxidici, metaboliti ai hidrocarburilor

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7
Q

Care este DZ pentru tetraclorura de C?

A

90-100 ml

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8
Q

De ce nu mai este folosit cloroformul?

A

Sensibilizeaza cordul la catecolamine

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9
Q

Care sunt caracteristicile fizice ale CCl4?

A

Volatil
Miros eteric
NU ESTE INFLAM!!

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10
Q

Cum se elimină hidrocarburile alifatice?

A

PULMONAR!! 90%

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11
Q

CL4 este liposolubila/hidrosolubila?

A

LIPO!!! = depozitare in tesutul adipos, ficat și rinichi

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12
Q

Cum debuteaza intoxicatia cu CCl4?

A

Deprimare SNC
cefalee
slabiciune
ataxie
convulsii TC

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13
Q

Ce efecte II va avea intoxicatia cu CCl4?

A

Diaree
Febră
Hepatic: crestere transaminaze, icter, hepatomegalie, disfct hepatica, tulb de coagulare

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14
Q

La cate zile de la intoxicatia cu CCl4 apare afectarea hepatica?

A

3-4 zile

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15
Q

La cate zile de la intoxicatia cu CCl4 apare IH?

A

7z

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16
Q

Care este antidotul pentru intoxicatia cu CCl4?

A

N-acetilcisteina
DOZE: I. 140 mg/kgc
II. 70 mg/kgc la 4h, 3-4 zile
SE PREFERA IV, IN DILUTIE CU GLU 5%

17
Q

Se poate adm lapte in intoxicatia cu hidrocarburi alifatice?

A

NUUU
FF liposolubile

18
Q

Sub ce forma se poate produce intoxicatia cu dioxină?

A

DOAR SUB FORMA DE LAPTE DEDIOXINA
NU!!! inhalator

19
Q

Ce este dioxina?

A

Hidrocarbură aromatica polihalogenata, obtinuta inclusiv in urma arderii benzinei

20
Q

Cu cine interfera dioxina la nivelul nucleului?

A

Gene ce codifica citocrom P450
Gene ce codifica factorul de crestere epidermica
Receptori estrogeni
Interleukina 1beta

21
Q

Care sunt efectele clinice ale dioxinei?

A

Imunotoxicitate
Tox hepatica
Carcinogeneza
Teratogeneza
Cloracnee

22
Q

Unde se localizeaza cloraceneea?

A

Facial
Temporal
Periorbital
TX

23
Q

Care este trat pt intoxicatia cu dioxina?

A

ESTE DOAR SIMPT!!

Toxico - Theo (11 decks)

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