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PHRM 845 > HF loop diuretics > Flashcards

HF loop diuretics Flashcards

1
Q

What is the initial oral dose of furosemide (Lasix)?

A

20-40 mg QD or BID

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2
Q

What is the usual dose range of furosemide?

A

20-160 mg QD or BID

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3
Q

What is the dose of furosemide in pts w CrCl 20-50 ml/min?

A

160 mg QD/BID

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4
Q

What is the dose of furosemide in pts w CrCl <20 ml/min?

A

400 mg QD

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5
Q

What is the bioavailability of furosemide?

A

50% (10-70)

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6
Q

What is the half life of furosemide?

A

0.3-3.4 h

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7
Q

What is the duration of action of furosemide?

A

6-8 h

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8
Q

What is the initial oral dose of bumetanide (Bumex)?

A

0.5-1 mg QD or BID

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9
Q

What is the usual dose range of bumetanide?

A

1-2 mg QD or BID

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10
Q

What is the dose of bumetanide in pts w CrCl 20-50 ml/min?

A

2 mg QD/BID

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11
Q

What is the dose of bumetanide in pts w CrCl <20 ml/min?

A

8-10 mg QD

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12
Q

What is the bioavailability in bumetanide?

A

80-100%

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13
Q

What is the half-life of bumetanide?

A

0.3-1.5 h

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14
Q

What is the duration of action of bumetanide?

A

4-6 h

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15
Q

What is the initial oral dose of torsemide (Demadex)?

A

10-20 mg QD

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16
Q

What is the usual dose range of torsemide?

A

10-80 mg QD

17
Q

What is the dose of torsemide in pts w CrCl 20-50 ml/min?

A

40 mg QD

18
Q

What is the dose of torsemide in pts w CrCl <20 ml/min?

A

200 mg QD

19
Q

What is the bioavailability of torsemide?

A

80-100%

20
Q

What is the half-life of torsemide?

A

3-4 h

21
Q

What is the duration of action of torsemide?

A

12-16 h

22
Q

What is the initial oral dose of ethacrynic acid?

A

25-50 mg QD or BID

23
Q

What is the bioavailability of ethacrynic acid?

A

100%

24
Q

What is the IV equivalent doses of furosemide, bumetanide, and torsemide?

A

F 40 mg = B 1 mg = T 20 mg = E 50 mg

PHRM 845 (48 decks)

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