Hepatocellular carcinoma Flashcards
1
Q
HCC common risk
A
underlying liver disease
NASH/NAFLD
Cirrhotic patients
2
Q
How often cirrhotic patients screened
A
every 6mo and AFP (alpha fetoprotein)
3
Q
Imaging HCC
A
US/CT
MRI best sensitivity
**need to determine size of lesion
4
Q
Biopsy HCC
A
<1cm CT/MRI- follow every 3mo and assess for enlargement
1-2cm lesion- bx performed
over 2cm and elevated AFP- manage without biopsy
5
Q
HCC staging
A
1) tumor with no vascular invasion
2) tumor with vascular invasion or multiple tumors less than 5cm
3) multiple tumors over 5cm or involving major portal/hepatic vein
4) direct invasion of adjacent organs
6
Q
Screening HCC
A
HBV ptn
cirrhosis
7
Q
Prevent HCC
A
US/AFP every 6 mo
HBV vaccine programs
HBV/HCV tx
8
Q
Tx HCC
A
Surgery- only long-term cure - resection if tumor <5cm and no cirrhosis - liver transplant only cure Medical - sorafenib slows progression
