Colorectal screening and cancer, rectal cancer and anal cancer Flashcards

1
Q

When do you start obtaining a family history and when do you update it?

A

Age 20 and update every 5-10years

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2
Q

Who are we suspicious of for colorectal malignancy?

A

any patient over 40 with bowel changes and hematochezia

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3
Q

Who is average risk patient for colorectal screening?

A

asymptomatic and over 50 or over 45 if African American

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4
Q

When do we stop colorectal screenings?

A

over 85

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5
Q

Gold standard cancer prevention test?

A

colonoscopy every 10 years

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6
Q

Do we offer cancer prevention or cancer detection test first?

A

cancer prevention tests

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7
Q

Cancer detection tests

A

Annual fecal immunochemical test - don’t have to change diet, do at home and mail in
Annual fecal occult blood test- ptn can’t take aspirin or certain food; office or at home
Fecal DNA every 1-3 years- most sensitive; need to give a whole stool sample

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8
Q

If a cancer detection test is positive then do what?

A

cancer prevention test

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9
Q

Patient has one 1st degree relative with CRC or advanced adenoma less than 60yo

A

begin screening at age 40 or at an age 10 yrs younger than when person diagnosed. Get a colonoscopy every 5 yrs after.
Ex. Mother diagnosed at 45, you start getting tested at 35.

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10
Q

Patient has one first-degree relative with CRC or adenoma over 60 is screened how?

A

same as average risk person

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11
Q

Patient has over 2 first-degree relative with CRC or advanced adenoma of any age

A

begin screening at age 40 or at an age 10 yrs younger than when person diagnosed. Get a colonoscopy every 5 yrs after.
Ex. Mother diagnosed at 45, you start getting tested at 35.

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12
Q

Patient with lynch syndrome risk screening

A

Start at 20-25 or 10 yrs less than youngest affected relative and get colonoscopy every 1-2 yrs until 40, then yearly.
Genetic testing

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13
Q

Patient with FAP risk screening

A

Age 10-12 get sigmoidoscopy yearly
colonoscopy yearly after first polyp discovered
genetic testing

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14
Q

Patient with personal history of CRC

A

Total colon examination within 1 yr of resection and repeat at 3 yrs and 5 yrs if normal

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15
Q

Patient with personal history of adenoma

A

poylps removed and colonoscopy based on timeline

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16
Q

IBD patient

A

begin 8 years after onset of pancolitis

colonoscopy every 1-2 yrs

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17
Q

Who is most likely to get colorectal cancer?

A

age 50 -65; males; african americans

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18
Q

Where are colorectal cancers prevalent?

A

W. industrialized countries due to diet

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19
Q

Location of colorectal cancers

A

L. colon most common

R. colon is inherited in African Americans

20
Q

Cause of CRC

A

genetic and molecular alterations

21
Q

RF CRC

A
Modifiable
- W. diet (red meat, fats)
- obesity
- smoking
- alcohol
- diabetes
Non-modifiable
- African American
- Hereditary Polyposis Syndromes
- FHx of colon cancer
- increase in age
- IBD
- Childhood abdominal radiation
22
Q

Modifiable prevention CRC

A

diet and macronutrients- veggie, fruit, less red meat, fiber
physical activity
Low dose aspirin

23
Q

Clinical R. side CRC

A
  • vague abdominal pain
  • iron deficient anemia
  • fatigue
  • GI bleed
  • weakness due to blood loss
  • rectal bleeding
  • cachexia
  • weight loss
  • back pain
  • ascites
  • pallor
24
Q

Clinical L. side CRC

A
  • obstructive symptoms
  • colicky abdominal pain
  • change in bowel habits
  • constipation alternating with loose stools
  • stool streaked with blood
  • rectal bleeding
  • cachexia
  • weight loss
  • back pain
  • ascites
  • pallor
25
Q

Dx CRC

A

colonoscopy with biopsy

26
Q

Labs for CRC

A
LFT- elevated with metastasis
Carcionembryonic antigen (CEA) level- staging; drops/normalize means treatment working
CT chest and abdomen
27
Q

Staging CRC

A

T- depth of tumor penetration into the bowel wall
N- presence of lymph node involvement
M- presence/ absence of distant metastasis

28
Q

Tx CRC

A

Surgery- resection of primary colonic or rectal cancer is tx of choice
Chemo- stage 3 and 4
Radiation and chemo- rectal cancer stage 2-4 (decrease mass and preserve sphincter)

29
Q

Monoclonal antibodies that work against epidural growth factor receptor

A

cetuximab and panitumab; rash is good

30
Q

What is patient is KRAS and NRAS wildtype?

A

improved tx with monoclonal antibodies

31
Q

Clinical Rectal cancer

A
  • rectal tenesmus
  • urgency
  • recurrent hematochezia
  • narrow caliber stools
  • rectal bleeding
  • cachexia
  • weight loss
  • back pain
  • ascites
  • pallor
32
Q

What imaging can help with operative management of rectal cancer?

A

endorectal ultrasonography

33
Q

Tx rectal cancer

A
  • higher recurrence rate and lower long-term survival
    Stage 1= surgery
    Stage 2 and 3= chemoradiation and surgery
34
Q

Anatomy of anal cancer

A

tumors arise in mucosa- glandular, transitional, squamous

35
Q

Anatomy of peri-anal/anal margin cancer

A

arise distal to the squamous mucocutaneous junction or within the skin

36
Q

Where is the cutoff line in anal cancer?

A

pectinate line

37
Q

MC histology for anal cancer

A

Small cell carcinoma

38
Q

Cause of anal cancer

A

HPV

39
Q

RF anal cancer

A
HPV
Female
lifetime number of sexual partners
genital warts
smoking
HIV
receptive anal intercourse
chronic immunosuppresive condition
40
Q

Clinical anal cancer

A
  • rectal bleeding
  • anorectal pain
  • rectal mass sensation
  • rectal mass on digital rectal exam
  • condylomata
  • bleeding
41
Q

Initial Dx anal cancer

A

endoscopy with biopsy
anoscopy
rigid proctosigmoidoscopy

42
Q

Once dx work up of anal cancer

A

CT scan of abdomen/pelvis
PET
Fine needle aspirate or biopsy of node

43
Q

Stages of anal cancer

A

Stage 0-2= node negative
Stage 3= node +
Stage 4 = metastatic disease

44
Q

Tx anal cancer

A
Stage 0-3
- chemoradiotherapy: 5-FU + Mitomycin + radiotherapy
- surgery is disease progressing
Stage 4
-systemic chemo: cisplatin + 5-FU
- palliative chemoradiotherapy
45
Q

Post tx surveillance of anal cancer

A

Every 3-6 months for 5 yrs:
- DRE, anoscopy, inguinal node palpitation
CT chest, abdomen, and pelvis every 3 years