Hepatobilliary Tract Flashcards
Biliary
Liver dsea
Inc.bilirubin, alkphos, GGT
Hepatocyte Integrity
Liver disease
Increase AST, ALT, LDH
Synthetic function of hepatocyte
Inc. Prothrombin time, serum ammonia
Dec.serum albumin, aminopyrine breath test, galactose elimination
Ballooning degeneration (empty cytoplasm w/ remnants of cytoplasmic orgnelles)
Councilman bodies (eosinophilic globules)
Apoptosis
Bridging necrosis
Acute hepatitis
Ground glass hepatocyte
Bridging necrosis
Bridging fibrosis— hallmark
Chronic hepatitis
True or false
Fulminant hepatitis occurs 2-3wks after onset
Occurs in individuals who do not have chronic liver dsea.
Fulminant Hepatitis
Pyogenic vs nonpyogenic liver abscess
Pyogenic– bacteria
- - neutrophilic infiltrate
- - liquefactive necrosis
Nonpyogenic– echinococcal > (+) hooklets
amebic > anchovy paste
– eosinophilic
Unknown etiology
(+) anti-smooth muscle antibodies
Interface hepatitis with prominent plasma cells
Autoimmune hepatitis
True or false
Hepatic steatosis is completely reversible
True
Laennec cirrhosis
Mallory bodies
Brown shrunken, non fatty liver
Alcoholic hepatitis
Acquired hemochromatosis
Hemosiderosis
Triad of hemochromatosis
Hepatomegaly
DM
Bronze skin pigmentation
Deposition of hemosiderin is detected using what stain?
Prussian blue
Autosomal recessive
Impaired copper excreation
Failure to incorporate copper into Ceruloplasmin
Wilsons disease
Panlobular giant-cell transformation of hepatocyte
Prominent hepatocellular and canalicular cholestasis
Neonatal hepatitis
Non suppurative, inflammatory destruction of medium sized intrahepatic bile ducts
Inc. alkphos, cholesterol
(+) antimitochondrial antibodies
Primary billiary cirrhosis
Inflam. and obliterative fibrosis of intrahepatic and extrahepatic bile ducts
Charac. beading of contrast medium
Primary sclerosing cholangitis
Autoantibodies in primary sclerosing cholangitis
Atypical p-ANCA
Centrilobular necrosis
nutmeg liver, cardiac sclerosis
Chronic passive hepatic congestin
Obstruction of 2 or more hepatic veins
Tense liver capsule
Budd-chiari syndrome
Benign neoplasm of the liver asso.with oral contraceptive
Hepatic adenoma
Malignancy of the billiary tree arising from the bile ducts
Cholangiocarcinoma
Clonorchis and opistorchis infection is asso.with what malignancy
Cholangiocarcinoma
Perihilar extrahepatic form of cholangiocarcinoma
Klatskin tumor
True or false
Liver metastases is more common than primary hepatic neoplasia
True
Cholesterol vs pigment stone in cholelithiasis
Cholesterol stone– 90%, glistening radiating crystalline pallisade, radio opaque
Pigment stone
Black- sterile GB, oxidized Ca salts of Unconjugated bilirubin, radio opaque
Brown- infected intra and extrahepatic ducts, RadioLUCENT
Acute calculous vs acalculous
Calculous - chemical irritation and inflamm, no bacterial infection
Acalculous - ischemia (sepsis, trauma, burn etc.)
Rokitansky aschoff sinuses
Chronic cholecystitis
Most impt risk factor asso.with GB adeno ca
Gallstone
Common site of GB adeno ca
Fundus and neck
