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Micro-EX2- Tye > Hepatitis Viruses - Middleton > Flashcards

Hepatitis Viruses - Middleton Flashcards

1
Q

Where do the Hepatitis Viruses target?

A

The Liver

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2
Q

Hepatitis primarily infects and replicates in _______.

A

Hepatocytes

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3
Q

Hepatitis A: family, genome & Virion…..

A 
Family = Picornavirus 
Genome = (+) ssRNA 
Virion = Non enveloped
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4
Q

What are the modes of transmission for Hepatitis A?

A
  • Fecal-oral
  • Sexual
  • Parenteral
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5
Q

Hepatitis B: Family, Genome & Virion…

A 
Family = Hepadnaviridae 
Genome = Circular dsDNA
Virion = Enveloped
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6
Q

What are the modes of transmission for Hepatitis B?

A
  • Sexual
  • Vertical
  • Parental
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7
Q

Hepatitis C: Family, Genome & Virion..

A 
Family = Flaviviridae 
Genome = (+) ssRNA
Virion = Enveloped
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8
Q

What are the modes of transmission for Hepatitis C?

A
  • Sexual
  • Vertical
  • parenteral
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9
Q

Hepatitis Delta: Family, Genome & Virion…

A 
Family = Deltaviridae
Genome = (-) ssRNA 
Virion = Enveloped
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10
Q

Modes of transmission for Hep. Delta?

A
  • Sexual
  • Vertical
  • Parenteral
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11
Q

Hepatitis E: Family, Genome & Virion…

A 
Family = Calciviridae 
Genome = (+)ssRNA 
Virion = Non-enveloped
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12
Q

Modes of transmission for Hep. E?

A
  • Fecal-oral
  • Sexual
  • Parenteral
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13
Q

_____ & ____ are very rare in the US.

A

Hep. delta & Hep. E

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14
Q

_______ Causes food borne and waterborne hepatitis?

A

Hep. E

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15
Q

Is there any prevention available for Hep. E?

A

NO

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16
Q

HAV & HEV are very similar how can they be distinguished from each other?

A

by serology

17
Q

Best prevention of HAV?

A
  • Vaccine available = Havrix (killed vaccine)
18
Q

What are the symptoms of HAV? When do they resolve?

A

Maliase
anorexia
Vomiting & jaundice
*resolves approx. 8 weeks post infection.

19
Q

Best method of prevention for HCV?

A
  • No vaccine

- Interferon-alpha treatment helps reduce chances.

20
Q

What are the symptoms of HBV? When do they resolve?

A
  • Malaise
  • anorexia
  • Vomiting & fatigue
  • Jaundice
  • Elevated alanine levels
  • Recovery = approx. 3-4 months after onset of jaundice.
21
Q

HBV: Chronic disease occurs in _____ of cases.

A

5%

  • Sporadic episodes of hepatitis
  • cirrhosis of liver
22
Q

______ Requires an HBV infection first.

A

HDV!

23
Q

HBV: the genome encodes how many proteins?

A

one!

24
Q

What is the best prevention of HBV?

A

Vaccination

  • Requires multiple inoculations
  • not effective against chronic infection
  • Treatment for chronic case is interferon-alpha therapy & Nucleoside analogs: adefovir, lamivudine & tenofovir.
25
Q

Which Hepatits virus utilizes missing cap ribosomes to recognize interanl entry ribosomes entry site?

A

HCV

26
Q

What are the symptoms of HCV?

A
  • typically milder than HBV
  • 80% of infections are chronic
  • Extrahepatic disease = Mixed cryoglobulinemia

Micro-EX2- Tye (12 decks)

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