Hepatitis B Flashcards
Hepatitis B was discovered before?
Hepatitis C
Hepatitis B is more likely to cause chronic infection in?
Younger individuals
Family?
Hepadnaviridae
Genus?
Orthohepadnavirus
Genome?
dsDNA-RT
RC-DNA= Relaxed circular DNA
Partially dsDNA
RC-DNA stands for?
Relaxed circular DNA
Baltimore classification?
VII
100 times more infectious than?
HIV
Does integration into the host genome occur?
No
Replication occurs where?
Cytoplasm within the nucleocapsid
Stages of HBV infection?
Immune tolerant
Immune active
Inactive
What is associated with the immune tolerant stage?
Immune system not yet active
High levels of viral replication- active infection
High levels of HBeAg present in the blood
A person can remain in the immune tolerant stage for?
Decades
Immune active stage is usually entered in?
When children who were infected reach their thirties
Immune tolerant stage is associated with?
Inflammation, liver damage
Anti HBeAg antibody presence
Immune inactive stage is associated with?
Anti HBeAg
The infection can re-activate
Why is there less genome diversity in HBV?
Overlapping genomes
There are 4 ORFs which are overlapping
Each nucleotide is coding, sometimes for multiple proteins. Therefore mutations are rare as it is highly likely a mutation will lead to a dysfunctional protein
What antigens are associated with HBV?
HBsAg
HBcAg
HBeAg
The e in HBeAg stands for?
Early
High levels of HBeAg are indicative of?
Active infection
HBcAg?
This is not secreted
It is at the surface of the nucleocapsid
Remains associated with the viral particle at all times
HBsAg?
This is the surface antigen
Also known as the Australia antigen