Hepatitis Flashcards
What is hepatitis?
Inflammation of the liver and destruction of hepatocytes
What viruses cause hepatitis?
Hepatotropic viruses- they have an effect on the liver
What are the symptoms of hepatitis
Jaundice- yellowing of eyes/skin, elevated levels of transaminases present in the blood
What hepatotropic viruses are there?
Hepatitis A-E
Hepatitis C transmission?
Bloodborne
Hepatitis B transmission?
Bloodborne, unprotected sex, mother to baby
Hepatitis D can only infect those infected with?
Hepatitis B
Which hepatotropic viruses can cause chronic infection?
Hepatitis B, C and D
Genome of hepatitis C?
+ssRNA
Genome of hepatitis B?
dsDNA-RT
Baltimore classification of hepatitis C?
Group IV
Baltimore classification of hepatitis B?
Group VII
Is there a vaccine for hepatitis C?
No
Is there a vaccine for hepatitis B?
Yes
Is hepatitis B curable?
No
Is hepatitis C curable?
Yes
Hepatitis A and E are spread via?
Fecal oral route
Which people are most likely to develop chronic HBV infection?
Children
The risk decreases with age
When was HBV added to the routine vaccination programme in the UK?
2017
HCV symptoms in the beginning?
There are no symptoms of early infection
Tends to be asymptomatic
Hepatitis D can only infect individuals already infected with?
Hepatitis B
Chronic infection can progress to?
Liver cirrhosis, carcinomas or liver-failure
HBV is more infectious than HIV by how many times?
100 times more infectious than HIV
Children infected with HBV are at the greatest risk of developing?
Chronic infection
HBV genome?
dsDNA-RT
HCV genome?
+ssRNA
Majority of HCV infections become?
Chronic
Majority of individuals infected with HCV develop?
Chronic infection
What determines susceptibility to developing chronic HBV infection?
The age you are infected at
The young are much more vulnerable
Which hepatoviruses are spread through the fecal-oral route?
HEV and HAV
Which hepatoviruses result only in acute infection?
HEV and HAV
