HCV/HBV treatment Flashcards
Which virus was discovered first?
HBV
Which virus is curable?
HCV
Which virus is incurable?
HBV
Why is HBV incurable?
Due to the maintained cccDNA pool in the nucleus
Which virus is there a vaccine for?
HBV
Routine vaccination of HBV began when in the UK?
2017
Which virus replicates in the cytoplasm?
Both HBV and HCV
Which virus has a dsDNA genome?
HBV
Which virus has +ssDNA genome?
HCV
You are more likely to develop chronic HBV infection when?
You are younger
Most people infected with HCV develop?
Chronic infection
Which virus has a higher viraemia?
HBV
Which virus is more genetically diverse?
HCV
Which virus enters the nucleus?
HBV
Can HBV be cured?
No
HCV can be cured by use of?
Antivirals
Antiviral targets?
NS5B polymerase
NS5A which forms the membranous web
NS3/4A protease
Which drug can target replication?
Ribavirin
What is ribavirin?
Chain terminator
Nucleoside analogue
Which drug can inhibit the NS5B polymerase?
Sofosbuvir
Which drug can inhibit NS3/4A protease?
Telaprivir
What else can treat hepatitis infection?
PEGylated interferon
What is the function of PEG?
Makes the interferon last longer in the blood- fewer administrations required
HBV vaccine is made up of?
HBsAg subviral particles
How is the HBV vaccine made?
GM subunit
GM what is made?
GM yeast containing the gene for HBsAg and expressing HBsAg
What yeast?
Saccharomyces cereviseae
2018 who tested HBV on liver-on-a-chip?
Marcus Dorner at Imperial College
