hepatitis Flashcards
associations with autoimmune hepatitis
hypergammaglobulinaemia
HLA B8
DR3
antibodies present in type 1 autoimmune hepatitis
ANA or anti-smooth muscle antibodies (SMA)
affects both adults and children
antibodies in type II autoimmune hepatitis
anti-liver/kidney microsomal type 1 antibodies (LKM1)
affects children only
antibodies in type III autoimmune hepatitis
soluble liver-kidney antigen
affects adults in middle age
features of autoimmune hepatitis
signs of chronic liver disease
acute hepatitis: fever, jaundice
amenorrhoea
ANA/SMA/LKM1 antibodies, raised IgG
liver biopsy: inflammation beyond limiting plate
management of autoimmune hepatitis
steroids or other immunosuppressants- azathioprine
liver transplant
transmission of hep A
faecal-oral spread
presentation of hep
flu like prodrome
abdo pain- RUQ
tender hepatomegaly
jaundice
deranged LFTs
transmission of hep B
blood or bodily fluids
features of hep B
fever
jaundice
elevated liver transaminases
management of hep B
pegylated interferon-alpha
other antiviral:
- tenofovir, entecavir, telbivudine
what marker for hep B implies acute disease
HBsAG (present for 1-6 months)
what marker in Hep B implies immunity
anti-HBs
what marker in hep B implies previous or current infection
anti-HBc
what marker in hep B implies infectivity
HbeAG
pathophysiology of hep C
RNA flavivirus
presentation of hep C
transient rise in serum aminotransferases/ jaundice
fatigue
arthralgia
investigations for hep C
HCV RNA investigation of choice in acute infection
definition of chronic hep C
persistence of HCV RNA in blood for 6 months
diagnosis of hep D
reverse polymerase chain reaction of hepatitis D RNA
treatment of hep D
interferon
spread of hep E
faecal-oral route
in central and south-east asia, north and west africa and mexico
