coeliac disease

Question 1

management of coeliac disease

Answer 1

gluten free diet
have function hyposplenism: pneumococcal vaccine

Question 2

signs and symptoms of coeliac disease

Answer 2

chronic or intermittent diarrhoea
failure to thrive or faltering growth
persistent GI symptoms: nausea and vomiting
prolonged fatigue
recurrent abdo pain and cramping
weight loss
anaemia

Question 3

complications of coeliac disease

Answer 3

anaemia
hyposplenism
osteoporosis, osteomalacia
lactose intolerance
enteropathy-associated T cell lymphoma of small intestine
subfertility

Question 4

investigations for coeliac disease

Answer 4

reintroduce gluten
TTG antibodies (IgA) first line
endomyseal IgA- need to look for selective IgA deficiency
IgG
endoscopic intestinal biopsy- gold standard
- villous atrophy, crypt hyperplasia, increase intraepithelial lymph, lamina propria infiltration with lymph