hemostasis & thrombosis Flashcards
platelet aggregation mechanism
damaged blood vessel
->
subendothelial matrix exposed
->
platelet glycoprotein receptors (GPIb) bind to vWF protein
->
signals to activate platelets & secrete granules from platelets
->
platelet aggregation
coagulation cascade pathway
fibrinolysis pathway
5 types of deficiencies in blood clotting proteins
hemophilia A, B, C
vitamin K deficiency
Von Willebrand disease type I, II, III
hereditary thrombolic disorders
factor 2, 5, 7, 10, 12 deficiencies
2 types of hereditary thrombolic disorders
factor 5 Leiden
prothrombin mutation
Von Willebrand disease
-prevalence
-inheritance
-different types
most common inherited blood-clotting disease
autosomal dominant w incomplete penetrance
type I (heterozygous, common)
type II
type III (severe, rare)
what is thrombocytopenia
low platelets
antiplatelet drugs
-heparin
-warfarin, vitamin K
-direct thrombin inhibitor
-factor 10a inhibitor
-aspirin
-ADP receptor site inhibitor
-GP2b-3a antagonist
aspirin mechanism of action
inhibits COX1/2 & COX1
prevents platelet production of Txa2
GP2b-3a antagonist mechanism of action
prevents platelet aggregation
what is PT (prothrombin time)
add tissue factor to assay & assess time to form clot
what is aPTT blood test
(activated partial thromboplastin time)
what is in assay without tissue factor present
