HEMOGLOBINOPATHIES and THALASSEMIA

Question 1

HEMOGLOBINOPATHIES

A. QUALITATIVE
B. QUANTITATIVE

Answer 1

QUALITTATIVE (MUKA/ APPEARANCE ANGMAY PROBLEM)

Question 2

SEVERE FORM / BOTH GLOBIN IS AFFECTED

A. HETEROZYGOUS / TRAIT CONDITION
B. HOMOZYGOUS / DISEASE CONDITION

Answer 2

HOMOZYGOUS

Question 3

SICKEL CELL DISEASE IS IMMUNE IN WHAT PARASITE

a. plasmodium falciparum
b. plasmodium vivax
c. plasmodium malariae

Answer 3

plasmodium falciparum

Question 4

most common cause of death of patient with sickle cell disease

a. dehydration
b. bacterial infection
c. low blood pressure

Answer 4

bacterial or infectious crisis

Question 5

old method in screening sickle cell disease

a. hemoglobin electrophoresis
b, sodium metabisulfite test
c. dithionite solubility test

Answer 5

sodium metabisulfute test - old method on screening

dithionite solubility test - most commonly used screening

hemoglobin electrophoresis, HPLC or capillary electrophoresis - confirmatory

Question 6

characterized by barr of golds crystals

a. hb s
b. hb as
c. hb cc

Answer 6

hgb c disease / hgb c

Question 7

caused by LYSINE replaces GLUTAMIC ACID at position 6 on BOTH chains

a, sickle celll disease

b. hgb E
c. hgb c disease

Answer 7

hgb c disease - position 6

hgb E - caused by lysine replaces glutamic acod at position 26 on beta chain

Question 8

caused by VALINE replaced by glutamic acid at position 6 on BOTH chains

a. sickle cell disease
b. sickle cell trait
c. hb c disease

Answer 8

sickle cell disease - both chain

sickle cell train (HB as) - one chain