hematopoiesis Flashcards

1
Q

these type of human stem cell are present in the FIRST FEW HOURS after ovum is fertilized

a. totipotential stem cell
b. pluripotential stem cell
c. multipotential stem cell

A

totipontial stem cell

  • develop in the few hours
  • most versatile
  • can develop into any human cell type including the development from embryo to fetus
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2
Q

it is a stem cell THEORY that suggests that all blood cells are derived from a single progenitor stem cell that is called PLURIPOTENT stem cell

a. monophyletic theory
b. polyphyletic theory

A

monophyletic theory

  • it has one stem cell progenitor
  • most accepted theory
  • isang kumpol na bata ay may isa lang na MAMA
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3
Q

it is a stem cell theory that suggest that each of the blood cell lineages is derived from its own unique stem cell

a. monophyletic theory
b. polyphyletic theory

A

polyphyletic theory

  • blood cells has own unique stem cell
  • ang isa anak may kakaiba ugali/ may tig iisa nanay
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4
Q

HEMATOPOIESIS is a continuous regulated process of blood cell production that includes

a, cell renewal, proliferation,differentiation and apoptosis

b. self renewal, differentiation, maturation and apoptosis
c. cell renewal, proliferation, differentiation and maturation

A

hematopoiesis — CELL renewal, Proliferation, differentiation and maturation

HEMATOPOIETIC MICROENVIROMENT – SELF renewal, proliferation, differentiation and APOPTOSIS

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5
Q

hematopoietic microenviroment is ideal enviroment in HSC is the allowance for:

a. cell renewal, proliferation,differentiation and apoptosis
b. self renewal, differentiation, maturation and apoptosis
c. cell renewal, proliferation, differentiation and maturation

A
hematopoietic microenviroment:
SELF renewal
proliferation
differentiation
APOPTOSIS
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6
Q

THREE STAGES OF HEMATOPOIETIC DEVELOPMENT

a. totipotential stem cell, pluripotential stem cell, multipotential stem cell
b. mesoblastic, hepatic and medullary

A

three stage of hematopoietic DEVELOPMENT

  1. mesoblastic phase
  2. hepatic phase
  3. medullary phase
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7
Q

three TYPES of human stem cell

a. totipotential , pluripotential, multipotential
b. mesoblastic, hepatic and medullary

A

THREE TYPES OF HSC

  1. totipotential stem cell
  2. pluripotential stem cell
  3. multipotential stem cell
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8
Q

it is a stage where primative erythroblast form

a. heapatic phase
b. mesoblastic phase
c. totipotential

A

mesoblastic phase

  • formation of PRIMATIVE ERYTHROBLAST
  • STAGE FOR PRIMATIVE HEAMTOPOEISIS
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9
Q

WHAT IS THE MAJOR SITE FOR HEPATIC PHASE

a. yolk sac
b. liver
c. bone marrow

A

liver - hepatic phase

yolk phase - mesoblastic phase

bone marrow - medullary phase

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10
Q

it is the stage for beginning of definitive hematopoiesis

a. hepatic phase
b. mesoblastic phase
c. totipotential

A

hepatic phase

  • start of definitive hematopoiesis
  • detectable hgb
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11
Q

the process of replacing the active marrow (red) by adipocytes (yellow) during development is called?

a. sternum
b. retrogression
c. apoptosis

A

retrogression

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12
Q

tissue basophil

a. macrophage
b. mast cell
c. osteoblasts

A

mast cell

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13
Q

normal marrow cells that is mistaken as PLASMA CELLS

a. macrophage
b. mast cell
c. osteoblasts
d. osteoclasts

A

osteoblasts

  • bone forming cells (bform)
  • WATERBUG OR COMET appearance
  • mistaken as PLASMA CELLS
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14
Q

normal marrow cells that is mistaken as MEGAKARYOCYTES

a. macrophage
b. mast cell
c. osteoblasts
d. osteoclasts

A

Osteoclasts

  • bone resorption or destroying cells
    (ung CLASS na yon nakakasra)
  • mistaken as MEGAKARYOCYTES
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15
Q

the LARGEST cell in the BM

a. metamyelocyte
b. megakaryocyte
c. monocyte

A

largest cell in bm - MEGAkaryocyte

largest cell PB - monocyte

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16
Q

most predominant cell in BM

a. metamyelocyte
b. megakaryocyte
c. monocyte

A

most predominant cell in BM - metamyelocyte

largest cell in bm - MEGAkaryocyte

largest cell PB - monocyte

17
Q

in white pulp where T cells resides

a. PALS
b. Primary follicles
c. Germinal center

A

PALS (periarteriovascular lymphoid shealths) – t cells resides

primary follicles - where B cells resides

germinal center/ secondary follicle - ACTIVATED b cell reside

18
Q

cord of billroth

a. white pulp
b. red pulp

A

red pulp

19
Q

removal of senescent RBC

a, red pulp
b. white pulp

A

red pulp

20
Q

removal of mature/ senescent rbc through phagocytisis leads to extravascular hemolysis

a. culling
b. pitting

A

culling

21
Q

removal of cell inclusions

a. culling
b. pitting

A

pitting

22
Q

abscence of splenic function maybe caused by either surgical removal or radiation exposure

a. asplenia
b. hypersplenism / splenomegaly
c. autosplenectomy

A

asplenia / splenectomy

  • undergo na nang surgery
  • lead to PANCYTOSIS