erythropoiesis Flashcards
first morphological identifiable rbc precursor
a. Reticulocyte
b. pronormoblast
c. Erthrocyte
pronormoblast
how many days does reticulocyte remain in the bone marrow to released in the circulation
a. 1-2 days
b. 24 hrs
c. 1-4 days
1-2 days
major stimulus
a. hypoxia
b. testosterone
c. thyroid hormone
hypoxia - major stimulus
other stimulus
a. testosterone –> directly stimulate in erythropoeiesis
b. Pituitary and thyroid hormone –> indirect EFFECT to erythropoiesis
how many days does BFU-E to mature to an RBC
a. 2-3 days
b. 18- 21 days
c. 18-25 days
18- 21 days
the CFU-GEMM give rise to the earliest identifiable colony of RBCs, called the ___________that contains on few receptors of EPO
a. CFU-e
b. BFU-e
c. pronormoblasts
BFU-e
early morphologically recognizable precursor
a. rubriblasts
b. pronormoblasts
c. proerythrocyte
aota
last stage of mitosis
a, rubriblasts
b. rubricyte
c. prorubricyte
d. metarubricyte
rubricyte / polychromatophilic
- last stage of mitosis
- 1st stage of hgb synthesis
last nucleated stage
a, rubriblasts
b. rubricyte
c. prorubricyte
d. metarubricyte
e. reticulocyte
metarubricyte
it has pyknotic nucleus
a, rubriblasts
b. rubricyte
c. prorubricyte
d. metarubricyte
metarubricyte
last stage in production of HGB
a, rubriblasts
b. rubricyte
c. prorubricyte
d. metarubricyte
e. reticulocyte
RETICULOCYTE
TRUE OR FALSE
EPO ACCELERATES THE RATE OF mRNA AND PROTEIN SYNTHESIS
TRUE
function of EPO
INCREASE OR DECREASE
________ the time of maturation of metarubricyte
decrease
bone marrow transit time for
pronormoblast
a. 24 hrs
b. 30 hrs
c. 48 hrs
24 hrs
pronormoblasts and basophilic normoblasts/ prorubricyte
bone marrow transit time for Polychromatophilic normoblasts
a. 24 hrs
b. 30 hrs
c. 48 hrs
polychromatophilic normoblasts / rubricyte
30hrs
serves as major cellular anchor for rbc
a. monocyte
b. lymphocyte
c. macrophage
MACROPHAGE
they serves as transport and adhesion sites and signaling receptors
a. integral/ transmembrane proteins
b. cytoskeleton / peripheral proteins
c. external surface
integral proteins / transmembrane proteins
major proteins that provides deformability to rbc
a. ankyrin
b. spectrin
c. actin
spectrin
pathway that is Major energy provider
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
embden meyerhof pathway`\
how many anaerobic glycolysis does emp have?
a. 95%
b. 90%
c. 10%
90% Anaerobic glycolysis
how many AERobic glycolysis does HMP have
a. 90%
b. 1%
c. 10%
10% AERobic pathway
how many atp molecules does EMP have?
a. 2 atp
b. 3 atp
c. 1 atp
2 atp molecules
most common enzyme deficiency in EMP
a. pyruvate kinase
b. g6pd
c. methemoglobin
pyruvate kinase
pathway that extends the rbc lifespan
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
hmp
provides reduced glutathione to prevent oxidative denaturation of hemoglobin
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
hmp
most common inherited enzyme deficiency in HMP
a. pyruvate kinase
b. heinz bodies
c. g6pd
g6pd -most common inherited enzyme deficiency in HMP ans associated with heinz bodies
g6pd is an enzyme deficiency of hmp that is associated with
a. giant platelets
b. howell jolly bodies
c. heinz bodies
heinz bodies
involved in reducing ferric ions to ferrous iron
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
methemoglobin reductase or Cytochrome B5 reductase
Increase 2, 3 -DPG = decrease hgb to oxygen
a. shift to Right
b. shift to left
shift to Right
decrease 2, 3 -DPG = increase hgb to oxygen
a. shift to Right
b. shift to left
shift to left
maintains the cellular energy by generating the ATP
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
EMP
prevents denaturation of globin of the hgb molecule by oxidation
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
hmp
prevents oxidation of heme iron
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
methemoglobin reductase
regulates oxygen affinity of hgb
a. emp
b. hmp
c. methemoglobin reductase pathway
d. rapaport leubering pathway
rapport luebering pathway
what shape does oxygen dissociation curve have
a. biconcave
b. sigmoid
c. square
sigmoid
what are the decrease in shift to the left
a. ph
b. pco2
c. 2,3 - DPG
d. temperature
c. hb affinity for O2
shift to the left
a. ph - increase
b. pco2 - DECREASE
c. 2,3 - DPG - DECREASE
d. temperature - DECREASE
c. hb affinity for O2 - increase
what are the increase in shift to the right
a. ph
b. pco2
c. 2,3 - DPG
d. temperature
c. hb affinity for O2
shift to the RIGHT
a. ph - decrease
b. pco2 - INCREASE
c. 2,3 - DPG - INCREASE
d. temperature - INCREASE
c. hb affinity for O2 - decrease
CaDeT face to the RIGHT
what effect have when there is change in pH
a. sigmoid
b. Bohr
c. culling
bohr effect
haptoglobin values inn intravascular hemolysis / fragmentation hemolysis
a. decrease
b. increase
decrease
