Hemoglobinemias Flashcards
1
Q
Rhabdomyolysis
A
high myoglobin in blood stream; Muscle breakdown
2
Q
Beta-thalasemmia
A
Mutation of 1st position of Intron 2; G->A mutations, thus Exon 1 is spliced out caused reduction or absent synthesis of Beta sheets in Hemoglobin; Sx: microcytic hypochromic anemia
3
Q
Sickle cell anemia
A
valine (hydrophobic) substituted for glutamic acid on hemoglobin (hydrophilic), deformed erythrocytes rupture easily causing anemia and/or clots
