Hemoglobin A1c by Tosoh HPLC

Question 1

Discuss the principle of the Tosoh instrument used for measurements fo Hemoglobin A1c.

Answer 1

-

Question 2

Discuss the clinical usefulness of Hemoglobin A1c measurements in Detail

Answer 2

-

Question 3

List the percentage of hemoglobin A1c that is recommended as a primary goal of therapy

Answer 3

-

Question 4

What should be done if the patient’s result shows that the non-A hemoglobin elutes prior to the A0 peak?

Answer 4

-Hgb electrophoresis to confirm

Question 5

What should be done if a patient ahs no hemoglobin A?

Answer 5

-Recommend a fructosamine level assay

Question 6

List how glycated hemoglobin results affect in patients with the hemolytic anemia

Answer 6

-The life span of RBC is shortened, this will cause decrease glycol hemoglobin

Question 7

List how glycated hemoglobin results affect in patients with polycthemia and/or post splenectomy

Answer 7

-RBC life span is lengthened, this will cause increase in glycol hemoglobin