Hemodynamics #5 Flashcards
Phosphodiesterase Inhibitors action / indication
Second line drug not used often. (For beta receptor down regulation)
- Beta Receptor stimulation causes ATP to be converted to cyclic AMP
- CAMP makes everything happen with cell.
- cAMP broken down w/ phosphodiesterase
- beta downregulation due to continuous beta receptor stimulation.
- beta drugs are DC, phosphodiesterase inhibitors initiated.
Beta downregulation & steroid administration
Steroids tell RNA in cells to go into overdrive and create proteins which are used to create beta receptors
Cardiogenic shock vasopressin considerations
Pump failure - vasopressor stick a cork in the aorta.
-dopamine & Levophed May bridge temporarily.
Cardiogenic shock treatment
- Adding volume helps to a point then hurts,
- dopamine until dobutamine works
- dobutamine assists w/ decreasing afterload
- sodium Nitroprusside (nitropress) for vasodilation once BP maintained w/ dobutamine (let ventricles clear & prevent cardiomyopathies)
- IABP & LVAD therapy.
Normal Pressures: CVP CI PA PCWP SVR
CVP: 2-6 CI: 2.5-4.2 PA: 15-25(PAS) / 8-15 (PAD) PCWP: 4-12 SVR: 800-1200
CVP Waveform
Preload for R side of heart -hydration 1st, then RV function Waveform: Sloppy cursive M -A, C, V wave -CVP range: mean average of waves
Low CVP
- Hypovolemia
- Vasodilation / decrease preload
- Negative pressure ventilation
- spontaneous ventilation
- hyperventilation
High CVP
- Hypervolemia
- Obstruction upstream
- RV failure or RVI
- cardiac Tampanade
- positive pressure ventilation (always drops preload)
- pulmonary hypertension
- tight lungs
- PE
- pulmonic valve stenosis
- tricuspid stenosis / regurgitation
IJ Depth of Insertion (cm) CVP/ RA RVP PAP PCWP
IJ (10's) - Subclavian (+5) - Femoral (+20) CVP/ RA: 20 RVP: 30 PAP: 40 PCWP: 50
Subclavian Depth of Insertion (cm)
IJ (10's) - Subclavian (+5) - Femoral (+20) CVP/ RA: 25 RVP: 35 PAP: 45 PCWP: 55
Femoral Depth if Insertion (cm)
IJ (10's) - Subclavian (+5) - Femoral (+20) CVP/ RA: 40 RVP: 50 PAP: 60 PCWP: 70
Positive pressure ventilation benefits and complication
Right heart friendly during failure (gives Chambers ability to clear)
Not left heart friendly during failure (need to improve preload on left side)
RVP
-Not typically monitored
-can irritate ventricle causing VF/VT
-looks similar to VT
-Sharp upstroke and down stroke
-notching on ascending side indicates atrial kick
-Anachrotic Notch
-norm: systolic: 15-25, diastolic:0-5
(Diastolic Must be lower than CVP)
Pressures: Single vs fractional numbers
Single: mean numbers (preloads)
2 numbers: arterial (after loads)
PA waveform
R heart output, L heart preload
- Pulmonary compliance
- PAS: same as RVP
- PAD: higher than RVDP (pulmonic valve closes and hold pressure for backflow into RV)