Heme Synthesis Flashcards
which out of the following is not a hemo protein
a)Tryptophan pyrrolase
b)tyrosinase
c) myoglobin
d) cytochrome P450
Tyrosinase
which of the following enzymes catalyze a rate limiting step in the pathway of heme biosynthesis
ALA Synthase
High levels of lead can affect heme metabolism by combining with SH groups of which enzymes
ALA dehydratase
Pyridoxal phosphate is necessary for the pathway of Heem biosynthesis, which out of the following enzyme requires pyridoxal phosphate as a coenzyme
ALA Synthase
in general, the porphyrias are inherited in an autosomal dominant manner with the exception of
Congenital erthropoietic porphyria
Formation of ALA occurs in
Mitochondria
Uroporphyrinogen formed is almost exclusively
The III isomer
Coproporphyrinogen oxidase is able to act only on
Type III isomer
in which of the following porphyrias cutaneous hypersensitivity is not observed
Congenital Erthyropoietic porphyria
which of the following statements describes the basis of giving IV hemin infusion
a) heme act as a negative regulator of the synthesis of ALA Synthase
B) Heme affects translation of the enzyme c) heme affects the transfer of enzyme from the cytosol to the mitochondria
D)all of the above
All of the above
Erythtrodontia is a sign of which porphyria
Congenital erthyropoeitic porphyria
in acute intermittent porphyria, the following enzymes deficiency is expected
Porphobilinogen decarboxylase
Porphyria cutanea tarda (patient with vesicles and bullae on his face and arms after spending so much time in the sun) is caused due to the deficiency of which enzyme
Uroporphyrinogen decarboxylase
patient with abdominal pain, cramping, anxiety, hallucinations, and paranoid behavior. What could be the diagnosis?
Variegate porphyria
patient with abdominal pain fever from seven days loss of appetite, pale stool and jaundice.blood biochemistry reveals mixed hyperbilirubinemia. What is the cause of jaundice?
Viral hepatitis
impaired Glucuronyl transferase activity is observed in all of the following, except
a)breastmilk jaundice
b)physiological jaundice of the newborn
c) Crigler Najjar syndrome
d)dubin Johnson syndrome
D) Dubin Johnson syndrome
Which of the following conditions is not associated with excessive bilirubin formation from hemolysis
a)sickle cell anemia
b)thalassemia
c)malaria
d)rotor syndrome
d) Rotor syndrome
which serum enzyme elevation is most diagnostic in obstructive jaundice
ALP alkaline phosphatase
Acholuric Jaundice is
Hemolytic Jaundice
urine analysis of a patient reveals the essence of bilirubin and urobilinogen which serum enzyme is expected to be elevated much higher than normal
ALT Alanine Aminotransferase
in conjugated hyperbilirubinemia which serum enzyme is expected to be much higher than normal for this patient
ALP (Alkaline phosphatase)
