Heme Onc Flashcards
Prostate ca mets to bone are osteobLASTIC and therefore best test to find these lesions is
Radioactive bone scan
Prior to starting doxorubicin, what study should be done?
Ventriculogram like radionuclide ventriculography. A decr in ef of 10% may warrant discontinuation.
Febrile nonhemolytic reaction pt should next receive what type of blood??
Leukoreduced- filters out wbc.
The above causes fever and malaise but no hemolysis. Bc during storage the leukocytes in blood release cytokines which causes this.
This blood also reduces transmission CMV
Acute hemolytic reaction presents as?
Tx?
Fever, FLANK pain, hemoglobinuria within 1 hr!!! May lead to renal failure and DIC.
Test positive for coombs
Due to not careful crossmatching
Obvs stop txn and give ivf
When should u warm blood?
During massive transfusion protocol to prevent hypothermia.
When should you WASH cells??
IgA def pts or with allergic reactions.
Wash out plasma which contains protein and ig
Polycythemia vera- expect what for EPO?
What does it mean when epo high?
Expect low epo. Can get jak2 mutation after
When epo high consider chronic hypoxia causing high epo. Ie sleep apnea. Test with nocturnal oximetry
Bleeding (epistaxis) in MM is due to?
Hyperviscosity syndrome- incr serum protein with large molecular size causing dizzy, vision change, dizziness
Causing impaired plt function
Tx is plasmapheresis
Once start tx for ida, what is first sign you see on labs?
Incr retic count bc before low retic count without iron
If pt with OP on alendronate doesnt respond and gets a fracture or keeps getting fractures what is next test?
Spep upep for MM. Also if have weight loss, constitutional symp.
What is tx of pagets disease?
Bisphosphonate will lead to resolution!
Tx when pain, high cqlcium
