Heme Onc Flashcards
Reticulocyte index that indicates BM is responding well
index >2%
Packed RBCs facts
no platelets of clotting factors
Mix with normal saline to infuse faster
Each unit raises Hct 3-4 points
Fresh frozen plasma indication
Contains all clotting factors
Given for high PT/PTT, coagulopathy, and deficiency of clotting factos
Cryoprecipitate indication
Contains factor VIII and fibrinogen
For hemophilia A, decreased fibrinogen (DIC and vWD)
Whole blood indication
Massive blood loss
Anaphylaxis in Blood transfusion
Within seconds to minutes
Due to ABO mismatched blood products
Symptoms: fever/chills, N/V, pain in flanks/back, chest pain, and dyspnea
Complications: hypovolemic shock, DIC, and renal failure with hemoglobinuria
Treatment: stop trasnfusion immediately, epinephrine, fluid replacement and dopamine/NE
Treatment and diagnosis of B thalassemia minor, intermedia and major
Diagnosis
Major: homozygous B chain
Intermedia: indeterminate
Minor: heterozygous B chain
Electrophoresis shows Hb F and Hb A2 are elated
Microcytic hypochromic anemia with target cells
Treatment: frequent packed RBC transfusions are required for major the other two are not treated
a -thalassemia trait, silent, Hb H and hydropsy fetalis diagnosis and treatment
diagnosis:
silent: one a locus deletion or mutation
No treatment
Trait: two a loci deletion or mutation
Mild microcytc hypochromic anemia
no treatment
Hb H: 3 loci deleted or mutated
signficant microcytic hypochromic anemia
electrophoresis shows (hemoglobin bart-B tetramers) Hb H
Treatment is packed RBC transfusions and possible splenectomy
hydrops fetalis: all four a loci are mutated or deleted
Fatal at birth
Treatment and diagnosis of aplastic anemia
Diagnosis: bone marrow biopsy-hypocellular marrow and absence of progenitor cells of all three cell lines
Treatment: bone marrow transplanation
Transfusion of packed RBCs and platelets if necessary
Treatment of B12 deficiency
parenteral cycanocobalamin once per month
Treatment of folic acid deficiency
daily oral folic acid replacement
General treatment of hemolytic anemia
Transfusion of packed RBCs is severe anemia or patient is hemodynamically unstable
Folate supplements
Blood transfusion indications for sickle cell
Acute chest syndrome, stroke, priapism that does not respond to fluids/analgesia, and cardiac decompensation
Diagnosis and treatment of hereditary spherocytosis
Diagnosis
Osmotic fragility to hypotonic saline RBCs undergo lysis at higher (thus earlier) oncotic pressure
Elevated reticulocyte count, elevated MCHC
Treatment:
Splenectomy
Diagnosis and treatment of warm autoimmune hemolytic anemia
Positive direct coombs test (RBCs coated with IgG)
Splenomegaly
Spherocytes
Treatment: glucocoricoids
Splenectomy
Immunosuppression with azothioprine or cyclophosphamide
RBC transfusions and folate supplements if necessary