Heme

Question 1

Causes of micro, normo, macrocytic anemia

Answer 1

Microcytics: TICS
Normocytic: chronic dz, hemolytic
Macrocytic: B12, folate

Question 2

This anemia will not respond to epo

Answer 2

Chronic dz

Question 3

Target cells, Howell-Jolly bodies

Answer 3

Sickle-cell

Question 4

Smooth tongue, glossitis, cheilosis

Stocking-glove paresthesia, loss of sensation, ataxia

Answer 4

B12 deficiency

Question 5

Pernicious anemia

Answer 5

Cannot absorb B12 (lack intrinsic factor)

Question 6

Triggered by drugs, infxn, fava beans

Bite cells, Heinz bodies

Answer 6

G6PD deficiency anemia

Question 7

Tx for G6PD def anemia

Answer 7

Self-limiting episodes

Question 8

Auer rods

Adults

Answer 8

AML

Question 9

Kids
Pancytopenia
Bone pain

Answer 9

ALL

Question 10

AML tx

Answer 10

Chemo + radiation/drugs

Question 11

ALL tx

Answer 11

Chemo + radiation/drugs (50% cure)

Question 12

Smudge cells

Older pts

Answer 12

CLL

Question 13

Philadelphia chromosome

Young to middle aged

Answer 13

CML

Question 14

CLL tx

Answer 14

Often harmless, but resistant to cure

Question 15

CML tx

Answer 15

Gleevac, bone marrow transplant

Question 16

Associated w/ EBV
Pain in node after alcohol
Reed-Sternberg cells

Answer 16

Hodgkin lymphoma

Question 17

Painless lymphadenopathy

Answer 17

Non-Hodgkin lymphoma

Question 18

Cancer of plasma cells
Rouleaux formation (RBC stack like coins)
Monoclonal spike
Bence Jones proteins in urine

Answer 18

Multiple myeloma

Question 19

Gingival bleeding

Answer 19

Von Willebrand

Question 20

Von Willebrand tx

Answer 20

Desmopressin

Question 21

Vit K dependent clotting factors

Answer 21

Factors 2, 7, 9, 10

Question 22

Factor 8 def, X-linked (males)

Answer 22

Hemophilia A

Question 23

Factor 9 def, X-linked (males)

Answer 23

Hemophilia B

Question 24

Factor V Leiden: clotting or bleeding d/o?

Answer 24

Clotting d/o

Question 25

Protein C & S deficiency: clotting or bleeding d/o?

Answer 25

Clotting d/o, C & S are natural anticoags

Question 26

Unopposed conversion of fibrinogen to fibrin

Answer 26

Antithrombin III deficiency

Question 27

Autoimmune, excessive platelet destruction

Follows viral infxn (1-4 wks later)

Answer 27

Idiopathic thrombocytopenic purpura

Question 28

Def of enzyme needed to cleave vWF

Schistocytes (RBC fragments)

Answer 28

Thrombotic thrombocytopenic purpura

Question 29

Idiopathic thrombocytopenic purpura tx

Answer 29

Self-limiting

Question 30

Thrombotic thrombocytopenic purpura tx

Answer 30

Plasma exchange, prednisone, antiplatelets