Heme Flashcards
med that reduces frequency of sickle cell crises
hydroxyurea
what are the 3 encapsulate bacterium(individuals with surgical splenectomy or sickle cell are at increased risk)
Pneumococcus, N meningitits, h flu
when does heparin related thrombocytopenia occur
501- day safter therapy
which laboratory test assess teh intrinsic coagulation pathway
partial thromboplastin time (apTT)
malignancies commonly associated with superior vena cava syndreom
non-hodgkin’s lymphoma and small cell carinoma of the lung
lab test for extrinsic coagulation pathway
prothrombin time
what is the final strep in clotting
converison fo fibrinogen to fibrin
MOA for dabigatran
direct rhrombin inhibitor (inhibits production of fibrin)
philadelphia chromosome is associated with what?
chronic myelogenosu leukemia
cause of pernicious anemia
destruction of pariteal cells in the stomach
common symptom in individuals with sickle cell trait in extreme conditions
painless hematuria/ rhabdo at high altitudes
hemolytic anemia + elevated LDH suggest what
TTP
punched out lytic lesions often found in spine
multiple myeloma
young patients which repeated aplastic crisis with spherocytosis should receive what?
splenecomty
diagnosis of malaria
demonstration of hte parasite in stained peripheral blood smears
Does ITP cause hemolysis?
no, but TTP does
bite cells are characteristic of what?
G6PD deficiency
Auer rods and pathognomonic for what?
AML
tx for Von Willebrand dz
vasopressin nasal spray (DDAVP) (also treats Factor VIII)
best test to confirm an immune mediated hemolytic anemia
Coombs test (direct- antibody on red cell membrane) indirect is antibody in the serum
