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PH 131 > Hematopoietic System > Flashcards

Hematopoietic System Flashcards

0
Q

Plasma membrane’s shape is dependent on what?

A

ATP

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1
Q

Dominant organelles at mature RBC

A

Mitochondria

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2
Q

RBC’s size indicates __.

A

Rate of production and destruction

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3
Q

True or False: RBC can change shape to fit thru small BVs

A

True

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4
Q 
The following biomolecules are needed in RBC prod except
A.vit B12
B.iron
C.folic acid
D.fructose
A

D.fructose

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5
Q

What hormone is needed for RBC prod and where is it produced?

A

Erythropoietin, kidney

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6
Q

Arrange sequence of hematopoietic organs: I.bone marrow, II.yolk sac, III.liver

A

II THEN III THEN I :)

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7
Q

As we age, red bone marrow becomes filled with ___. This is called yellow marrow

A.carbohydrates
B.proteins
C.adipose
D.ice

A

C.adipose

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8
Q

Absence of erythropoietin leads to ___ in committed erythropoietic cells

A

Apoptosis

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9
Q 
Sequencing
I.basophil erythroblast
II.reticulocyte
III.proerythroblast
IV.erythrocyte
A

III then I then II then IV

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10
Q

Basophilic erythroblast contains ____(little, abundant) hemoglobin

A

Little

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11
Q 
Which does not directly cause increased erythropoietin production?
A.anemia
B.hypoxemia
C.renal artery stenosis
D.low hemoglobin
E.impaired oxygen loading
F.low WBC count
A

F.low WBC count

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12
Q

Hemostasis can be directly achieved by the following mechanisms except:
A)vascular dilation
B)formation of platelet plug
C)formation of blood clot due to blood coagulation
D)growth of fibrous tissue into blood clot
E)blood filtration by kidneys

A

E)blood filtration by kidneys

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13
Q

Procoagulant forces promotes the following except
A)platelet adhesion
B)fibrin clot formation
C)vascular dilation

A

C)vascular dilation

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14
Q

Anticoagulant forces promote all except
A)vascular constriction
B)fibrinolysis
C)coagulation inhibition

A

A)vascular constriction

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15
Q

The vessel wall is a major component of the human hemostatic system, true or false?

A

True

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16
Q 
The following may cause blood vessels to constrict as hemostatic response...except:
A.local myogenic spasm
B.nervous reflex
C.thromboxane A2
D.dengue virus
A

D.dengue virus

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17
Q

This factor is primary mediator of platelet adhesion. Location:ECM of subendothelial wall and plasma

A

von Willebrand factor

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18
Q

Platelets directly bid to subendothelial ___ to facilitate platelet adhesion

A

Collagen

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19
Q

Platelet ___ complex: most abundant receptor on platelet surface. When active, it binds to fibrinogen & von Willebrand factor

A

Glycoprotein IIb/IIIa

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20
Q 
Platelet aggregation is enhanced by all except:
A.epinephrine
B.thrombin
C.adenosine diphosphate
D.serotonin
E.collagen
F.von Willebrand factor
G.fructose
A

G.fructose

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21
Q

Additional platelets are recruited to site of injury, leading to formation of ___

A

Platelet thrombus

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22
Q

When platelet plug is anchored, it is stabilized by ___

A

Fibrin mesh

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23
Q

Fibrin clot formation has 3 basic steps. Arrange natin!
I. Fibrinogen conversion to fibrin
II. Prothrombin becomes thrombin
III. Prothrombin activator is formed

A

III THEN II THEN I :)

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24
Q

Prothrombin activator converts prothrombin to thrombin in the presence of ___ ions

A

Calcium

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25
Q

___ converts fibrinogen to fibrin

A

Thrombin

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26
Q

T or F: plasma coagulation proteins normally circulate in their active forms

A

False. *inactive forms

27
Q

Extrinsic factor pathway is initiated by __

A

Material external to the blood

28
Q

Intrinsic factor initiated by __.

A

Blood coming in contact with exposed collagen at BV wall

29
Q

Coagulation is normally initiated through ___, which is composed mainly of phospholipids from membrane of damaged tissue + lipoprotein complex

A

Tissue factor/tissue thromboplastin

30
Q

____ pathway starts with release of tissue factor

A

Extrinsic

31
Q

Tissue factor combines with (A) and in the presence of (B) ions to form (C)

A

(A)factor VII
(B)Calcium
(C)Factor X

32
Q

Factor X combines with these to form prothrombin activator, except
A. Factor V
B.tissue phospholipids
C. Collagen

A

C.collagen

33
Q

The ___ pathway is composed of
Release of tissue factor
Activation of factor X
Formation of prothrombin activator

A

Extrinsic

34
Q

First step for intrinsic pathway

A

Factor XII activated,release of platelet phospholipids

35
Q

Factor XII is activated when it comes into contact with ___

A

Collagen

36
Q

In the 1st step of intrinsic pathway,platelets also release __

A

Platelet factor 3

37
Q

Second step, intrinsic pathway

A

Factor XI is activated

38
Q

Another name for Factor XI

A

Prekallikrein

39
Q

Factor XIIa activates Factor XI in the presence of high-molecular weight ____.

A

Kininogen

40
Q

. (3rd step, intrinsic pathway)

A

Factor XIa activates factor IX

41
Q

___ activates factor VII

A

Thrombin

42
Q 
The following activate Factor X in the intrinsic pathway,except?
A.factor IXa
B.factor VIIIa
C.platelet phospholipids
D.factor IIa
E.platelet factor 3
A

D.factor IIa

43
Q

(Intrinsic pathway)Factor Xa combines with the ff except __ to form prothrombin activator.
A. Tissue phospholipids
B.collagen
C.factor Va

A

B.Collagen

44
Q

Fibrinogen is also known as…

A

Factor I

45
Q

Prothrombin is also known as..

A

Factor II

46
Q

Tissue factor is also known as tissue thromboplastin &…

A

Factor III

47
Q

Calcium is also known as…

A

Factor IV

48
Q

Factor IX is also known as..

A

Christmas factor

49
Q

Common functions of prostacyclin, nitric oxide and ectoADPase/CD39

A

Inhibit platelet binding, secretion and aggregation

50
Q 
All are anticoagulant factors produce by endothelial cells except
A)prostaglandin
B)antithrombin
C)thrombomodulin
D)heparan proteoglycans
E)TF pathway inhibitor
A

A)prostaglandin

51
Q 
The following activate fibrinolytic mechanisms except
A.tissue plasminogen activator 1
B.urokinase
C.annexin-2
D.plasminogen activator inhibitor
E.hexokinase
A

E.hexokinase

52
Q

Neutralizes thrombin and other activated coagulation factors

A

Antithrombin

53
Q

Rate of antithrombin formation increasdd by ___

A

Heparin

54
Q

Plasma glycoprotein that becomes anticoagulant when activated by thrombin

A

Protein C

55
Q

Protein C activation (c/o thrombin) happens at___

A

Thrombomodulin

56
Q

How does Protein C become anticoagulant?

A

Cleaves and inactivates Factor V and VIII

57
Q

Protein C anticoagulant action accelerated by ____, which undergoes vitK dep posttranslational modification

A

Protein S

58
Q

regulates TF-induced extrinsic pathway of coagulation by inhibiting TF/VIIa/Xa complex

A

Tissue factor pathway inhibitor

59
Q

Major protease enzyme of fibrinolytic system

A

Plasmin

60
Q

Tissue type plasminogen activator (tPA) and ______ type plasminogen activator cleave ——– bond of plasminogen to generate plasmin

A

____:urokinase

—–:Arg560-Val561

61
Q

___-binding sites of plasmin permit it to bind to fibrin

A

Lysine

62
Q

Third step of fibrinolysis

A

Fibrin is cleaved by plasmin at diff sites —> fibrin fragments

63
Q

Primary inhibitor of tPA and uPA in plasma

A

PAI1

64
Q

Main inhibitor of plasmin in human plasma, inactivates any nonfibrin clot-associated plasmin

A

Alpha-2 antiplasmin

PH 131 (9 decks)

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